Priorities for endometriosis research: recommendations from an international consensus workshop.
Priorities for endometriosis research: recommendations from an international consensus workshop.
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DOI：
10.1177/1933719108330568
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Zondervan KT
中科院分区：
文献类型：
--
作者：
Rogers PA;D'Hooghe TM;Fazleabas A;Gargett CE;Giudice LC;Montgomery GW;Rombauts L;Salamonsen LA;Zondervan KT
子宫内膜异位症是一种雌激素依赖性疾病，子宫内膜组织在子宫外形成病变。据估计，育龄女性中约10%患有子宫内膜异位症，在不孕和/或疼痛患者中这一比例升至30% - 50%，对她们的身体、心理和社会福祉产生重大影响。目前尚无已知的治愈方法，而且由于副作用问题，大多数现有的药物治疗从长远来看并不适宜。据估计，子宫内膜异位症在美国每年的花费为188亿至220亿美元（2002年数据）。尽管子宫内膜异位症在100多年前就首次被描述，但目前对其发病机制、自然演变以及相关不孕和盆腔疼痛的病理生理学仍不清楚。在第十届世界子宫内膜异位症大会之后召开了一次共识研讨会，为子宫内膜异位症研究的重点提出建议。确定影响开展子宫内膜异位症研究能力的一个主要问题是需要多学科专业知识。共提出了25条研究建议，分为5个小标题：（1）诊断；（2）分类和预后；（3）治疗和结果；（4）流行病学；（5）病理生理学。与其他医疗负担较重的疾病相比，子宫内膜异位症研究资金不足。这可能是由于针对一种复杂且了解甚少、仅影响女性的疾病制定有竞争力的研究方案存在实际困难。通过制定这份国际共识研究重点声明，研讨会参与者希望能够鼓励研究人员制定新的跨学科研究方案，从而为子宫内膜异位症的研究工作吸引更多的资金支持。
Endometriosis is an estrogen-dependent disorder where endometrial tissue forms lesions outside the uterus. Endometriosis affects an estimated 10% of women in the reproductive-age group, rising to 30% to 50% in patients with infertility and/or pain, with significant impact on their physical, mental, and social well-being. There is no known cure, and most current medical treatments are not suitable long term due to their side-effect profiles. Endometriosis has an estimated annual cost in the United States of $18.8 to $22 billion (2002 figures). Although endometriosis was first described more than 100 years ago, current knowledge of its pathogenesis, spontaneous evolution, and the pathophysiology of the related infertility and pelvic pain, remain unclear. A consensus workshop was convened following the 10th World Congress on Endometriosis to establish recommendations for priorities in endometriosis research. One major issue identified as impacting on the capacity to undertake endometriosis research is the need for multidisciplinary expertise. A total of 25 recommendations for research have been developed, grouped under 5 subheadings: (1) diagnosis, (2) classification and prognosis, (3) treatment and outcome, (4) epidemiology, and (5) pathophysiology. Endometriosis research is underfunded relative to other diseases with high health care burdens. This may be due to the practical difficulties of developing competitive research proposals on a complex and poorly understood disease, which affects only women. By producing this consensus international research priorities statement it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.
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DOI：
10.1016/s1074-3804(98)80026-1
发表时间：
1998-08-01
期刊：
JOURNAL OF THE AMERICAN ASSOCIATION OF GYNECOLOGIC LAPAROSCOPISTS
影响因子：
--
作者：
Demco, L
通讯作者：
Demco, L
DOI：
10.1016/s0889-8545(05)70302-8
发表时间：
1997-06-01
影响因子：
3.2
作者：
Eskenazi, B;Warner, ML
通讯作者：
Warner, ML
影响因子：
2.1
作者：
Di, Wen;Guo, Sun-Wei
通讯作者：
Guo, Sun-Wei
影响因子：
6.1
作者：
Awwad, JT;Sayegh, RA;Isaacson, K
通讯作者：
Isaacson, K
影响因子：
6.1
作者：
Kato, Kiyoko;Yoshimoto, Momoko;Wake, Norio
通讯作者：
Wake, Norio