Interleukin-1 stimulates human chorionic gonadotropin secretion by first trimester human trophoblast.
Interleukin-1 stimulates human chorionic gonadotropin secretion by first trimester human trophoblast.
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Interleukin-1 刺激妊娠早期人类滋养层分泌人绒毛膜促性腺激素。
DOI：
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发表时间：
1989
影响因子：
5.8
通讯作者：
Robert F. Casper
中科院分区：
文献类型：
--
作者：
Simcha Yagel;P. Lala;Wendy A. Powell;Robert F. Casper
据报道，白细胞介素-1 (IL-1) 可刺激培养的垂体细胞释放 LH、GH、ACTH 和 TSH。还发现胎盘巨噬细胞大量分泌 IL-1。为了确定 IL-1 在胎盘中的可能作用，我们通过长期培养人妊娠早期滋养层和 JAR（人绒毛膜癌）细胞系，研究了人重组 IL-1 对 hCG 释放的影响。 IL-1浓度范围为10(-11)-10(-9) mol/L可刺激滋养层培养物中的hCG释放。这种刺激作用不是由前列腺素 E2 (PGE2) 介导的，吲哚美辛无法阻断这种刺激，而且 IL-1 对滋养层细胞释放 PGE2 缺乏影响，表明了这一点。在这些剂量下，IL-1 对 JAR 细胞释放 hCG 没有影响。当PGE2以高浓度（10(-6)-10(-5) mol/L）使用时，刺激滋养层和JAR细胞释放hCG。 IL-1 和 PGE2 都不刺激滋养层或 JAR 细胞的增殖、[3H]胸苷掺入或分化（合胞体形成）。这些结果表明 IL-1 可能是妊娠早期滋养细胞分泌 hCG 的重要局部调节因子。
Interleukin-1 (IL-1) has been reported to stimulate LH, GH, ACTH, and TSH release from cultured pituitary cells. IL-1 also has been found to be secreted in significant amounts by placental macrophages. To determine the possible role of IL-1 within the placenta, we studied the effects of human recombinant IL-1 on hCG release by long term cultures of human first trimester trophoblast and the JAR (human choriocarcinoma) cell line. IL-1 in concentrations ranging from 10(-11)-10(-9) mol/L stimulated hCG release from trophoblast cultures. This stimulatory effect was not mediated by prostaglandin E2 (PGE2), as indicated by the inability of indomethacin to block this stimulation as well as a lack of IL-1 effect on PGE2 release by trophoblast cells. At these doses, IL-1 exerted no effect on hCG release by JAR cells. PGE2, when used in high concentrations (10(-6)-10(-5) mol/L), stimulated the release of hCG by the trophoblasts as well as by the JAR cells. Neither IL-1 nor PGE2 stimulated the proliferation, [3H]thymidine incorporation, or differentiation (syncytium formation) of trophoblast or JAR cells. These results suggest that IL-1 may be an important local regulator of hCG secretion by first trimester trophoblasts.
人细胞滋养细胞中的腺苷酸环化酶：特征及其在调节人绒毛膜促性腺激素分泌中的作用。
DOI：
10.1210/jcem-66-2-258
发表时间：
1988
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Nulsen,JC;Woolkalis,MJ;Kopf,GS;Strauss3rd,JF
通讯作者：
Strauss3rd,JF
影响因子：
56.9
作者：
SAPOLSKY, R;RIVIER, C;VALE, W
通讯作者：
VALE, W
DOI：
10.1016/0002-9378(88)90810-1
发表时间：
1988-01-01
影响因子：
9.8
作者：
BERKOWITZ, RS;HILL, JA;ANDERSON, DJ
通讯作者：
ANDERSON, DJ