Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children.
Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children.
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环境香烟烟雾暴露调节了PB暴露儿童的IgE水平。
DOI：
10.1016/j.tox.2011.10.013
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发表时间：
2012-01-27
期刊：
影响因子：
4.5
通讯作者：
Neal RE
中科院分区：
文献类型：
--
作者：
Lutz PM;Kelty EA;Brown TD;Wilson TJ;Brock G;Neal RE
在以20世纪早期至中期住房为主的城市地区，存在着血铅水平（PbB）超过疾病控制与预防中心指南（bbb10 μg/dL）的儿童岛。这些儿童中有许多还暴露于环境烟草烟雾。目前的研究检查了来自密苏里州斯普林菲尔德-格林县市区的318名6-84个月儿童的铅暴露（多氯联苯水平为1-55 μg/dL）与/不同时暴露于ETS对免疫系统功能的影响。在该人群中，36.5%的儿童PbB水平为bb10 μg/dL， 62.9%的儿童来自吸烟家庭，51.9%的儿童年龄在2岁以下，人口符合WIC条件，主要为白人，非西班牙裔。多种免疫功能标志物，包括细胞计数、IgE水平、sCD25 （sIL2R）和IL4浓度，以及对常见儿童免疫的滴度，分析了与铅和/或ETS暴露的相关性。在CDC ii - iv级多氯联苯水平的儿童中发现IgE水平升高（p<0.01），这一发现主要归因于同时暴露于Pb和ETS的儿童亚群中IgE水平升高。在多氯联苯水平升高和ETS同时暴露的儿童中，总t细胞百分比增加（p=0.06）也有趋势（0.05<p<0.01）。在没有接触ETS的儿童亚组中没有发现这种趋势，在对整个人群的分析中也没有发现这种趋势。相反，在单独暴露于Pb（未同时暴露于ETS）的儿童亚群中，淋巴细胞百分比、粒细胞百分比和活化t细胞百分比的中位数发生了变化，尽管没有明显的趋势。在整个人群中，发现ETS和PbB水平之间存在统计学上显著的相关性。这项研究表明，先前报道的多氯联苯水平升高与血清IgE水平之间的相关性可能受到暴露于ETS的强烈影响。本研究的结果还表明，铅是一种免疫调节剂，多氯联苯水平可能受到ETS暴露的影响。
In urban areas with a predominance of early to mid-20th century housing stock, islands of children possessing blood lead levels (PbB) in excess of CDC guidelines (>10 μg/dL) exist. Many of these children are also exposed to environmental tobacco smoke (ETS). The current study examined the impact of Pb-exposure (PbB levels of 1-55 μg/dL) with/without concurrent ETS exposure on immune system function in 318 children aged 6-84 months from the urban area of Springfield-Greene County, Missouri. In this population, 36.5% of children possessed PbB levels >10 μg/dL, 62.9% of children came from smoking homes, 51.9% of children were under 2 years of age, and the population was WIC eligible and predominantly of white, non-Hispanic ethnicity. Multiple immune function markers including cell counts, IgE levels, sCD25 (sIL2R) and IL4 concentrations, and titers to common childhood immunizations were analyzed for correlation with Pb and/or ETS exposure. Increased IgE levels (p<0.01) were found in children with PbB levels within CDC Classes II-IV—this finding was primarily attributable to elevated IgE levels in the subpopulation of children with concurrent Pb and ETS exposure. A trend (0.05<p<0.01) of increases in % total T-cells (p=0.06) was also found in children with concurrent elevated PbB levels and ETS exposure. This trend was not found in the subset of children without ETS exposure nor was it present in the analysis of the entire population set. Conversely, alterations in median values for %Lymphocytes, % Granulocytes, and % Activated T-cells across Pb Classes were present in the subpopulation of children expose to Pb alone (without concurrent ETS exposure) though a clear trend was not evident. In the entire population set, a statistically significant correlation between ETS and PbB levels was found. This study indicates that prior reports of a correlation between elevated PbB levels and serum IgE levels may be strongly influenced by exposure to ETS. Findings from this study also indicate that Pb is an immune modulator and PbB levels may be influenced by ETS exposure.
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影响因子：
4.2
作者：
LUTZ, PM;BAUER, S;BENGSCH, H
通讯作者：
BENGSCH, H
影响因子：
10.3
作者：
Krämer, U;Lemmen, CH;Ring, J
通讯作者：
Ring, J
影响因子：
10.4
作者：
Joseph CL;Havstad S;Ownby DR;Peterson EL;Maliarik M;McCabe MJ Jr;Barone C;Johnson CC
通讯作者：
Johnson CC
DOI：
10.1016/0021-8707(67)90077-9
发表时间：
1967-01-01
期刊：
JOURNAL OF ALLERGY
影响因子：
--
作者：
BUCKLEY, RH;DEES, SC
通讯作者：
DEES, SC
影响因子：
8
作者：
Jones, Robert L.;Homa, David M.;Brown, Mary Jean
通讯作者：
Brown, Mary Jean