Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.
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DOI：
10.1038/s41467-021-25460-3
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发表时间：
2021-08-25
影响因子：
16.6
通讯作者：
Kenny PJ
中科院分区：
文献类型：
--
作者：
Smith ACW;Jonkman S;Difeliceantonio AG;O'Connor RM;Ghoshal S;Romano MF;Everitt BJ;Kenny PJ
相对而言，我们对新的工具性动作是如何在大脑中编码的知之甚少。使用全脑c-Fos映射，我们发现，神经活动增加，在前背外侧纹状体（aDLS）的小鼠，成功地学习一个新的压力响应，以赚取食物奖励。aDLS的学习后化学发生抑制破坏了新工具反应的巩固。类似地，学习后将蛋白质合成抑制剂茴香霉素输注到aDLS中破坏了新反应的巩固。在巩固过程中，表达D1受体的中型棘神经元（D1-MSNs）的活性增加，D2-MSNs活性降低。aDLS中D1-MSN的化学发生抑制破坏了巩固过程，而D2-MSN抑制加强了巩固，但阻断了先前学习的习惯样反应的表达。这些发现表明，D1-MSNs在aDLS编码新的工具性行动，而D2-MSNs反对这种新的学习，而是促进表达习惯性行动。新的工具性学习是通过意外地提供奖励刺激或撤回惩罚刺激而发生的。作者表明，D1受体表达中棘神经元（MSN）在前背外侧纹状体编码新学习的工具性行动，而D2 MSN促进表达习惯性行动。
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions. New instrumental learning occurs through an unexpected delivery of a rewarding stimulus or the withdrawal of a punishing stimulus. The authors show that D1 receptor-expressing medium spiny neurons (MSNs) in the anterior dorsolateral striatum encode newly learned instrumental actions whereas D2 MSNs promote the expression of habitual actions.
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影响因子：
2.4
作者：
Cardinal RN;Cheung TH
通讯作者：
Cheung TH
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
25
作者：
Gritton, Howard J.;Howe, William M.;Han, Xue
通讯作者：
Han, Xue
背侧和腹侧：纹状体子区域在目标指导作用的采集和性能中的独特作用。
影响因子：
2.7
作者：
Hart G;Leung BK;Balleine BW
通讯作者：
Balleine BW
影响因子：
16.2
作者：
Guenthner CJ;Miyamichi K;Yang HH;Heller HC;Luo L
通讯作者：
Luo L