Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters.
Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters.
复制标题
DOI：
10.3390/molecules21030313
复制
发表时间：
2016-03-05
期刊：
影响因子：
--
通讯作者：
Wang MF
中科院分区：
文献类型：
--
作者：
Huang WC;Lin CL;Hsu YJ;Chiu YS;Chen YM;Wu MF;Huang CC;Wang MF
抗性碳水化合物菊粉和Fibersol-2属于可溶性膳食纤维，被认为是维持生物功能的重要益生元，包括葡萄糖稳态，脂质调节，结肠疾病预防和益生元特性。然而，很少有研究调查Fibersol-2单独或与菊粉组合，以评估对高脂血症调节的合并效应。我们的目的是研究这种组合补充剂（定义为InF）对喂食0.2%胆固醇和10%猪油饮食（即，高胆固醇饮食，HCD）诱导高脂血症。将共计40只雄性仓鼠随机分配至5组（每组n = 8）进行给药：标准饲料、溶剂（对照）;或以0、864、1727或2591 mg/kg/天剂量经口灌胃补充溶剂或InF，持续8周，分别指定为HCD、InF-1X、InF-2X和InF-3X组。通过血脂指标、肝脏和粪便脂质含量以及组织学检查评估补充InF的降血脂效果和安全性。治疗2周后，补充InF显著改善了血清三酰甘油（TG）和低密度脂蛋白胆固醇（LDL-C）水平以及LDL-C/HDL-C比值，并在4周后降低了血清总胆固醇（TC）水平。补充8周后，补充InF剂量依赖性地改善血清TC、TG、HDL-C和LDL-C水平; LDL-C/HDL-C比值;以及肝脏TC和TG水平。通过粪便排泄抑制TC吸收。我们的研究提供了基于实验的证据来支持这种益生元疗法可能有助于预防或治疗高脂血症。
The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia.
登录
查看更多内容
影响因子：
1.9
作者：
Nelson, Robert H.
通讯作者：
Nelson, Robert H.
影响因子：
7.1
作者：
Roberfroid, MB
通讯作者：
Roberfroid, MB
DOI：
10.3305/nh.2015.31.2.7706
发表时间：
2015-02-01
期刊：
Nutrición Hospitalaria
影响因子：
--
作者：
Reis, Sandra Aparecida dos;Conceição, Lisiane Lopes da;Peluzio, Maria do Carmo Gouveia
通讯作者：
Peluzio, Maria do Carmo Gouveia
影响因子：
5.9
作者：
Lee LC;Wei L;Huang WC;Hsu YJ;Chen YM;Huang CC
通讯作者：
Huang CC
影响因子：
3.5
作者：
Ooi, L. -G.;Ahmad, R.;Liong, M. -T.
通讯作者：
Liong, M. -T.