Influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma: a meta-analysis of observational studies.
Influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma: a meta-analysis of observational studies.
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DOI：
10.1186/1477-7819-9-108
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发表时间：
2011-09-21
影响因子：
3.2
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Zhou Y;Si X;Wu L;Su X;Li B;Zhang Z
病毒性肝炎状态对肝细胞癌肝切除术患者预后的影响仍是一个有争议的问题。这项研究是对现有证据的荟萃分析。对文献进行检索，以确定不同类型病毒性肝炎中肝细胞癌术后存活率的比较研究。采用固定效应模型和随机效应模型计算合并优势比(OR)和加权平均差异(WMD)，95%可信区间(95%CI)。20项研究符合选择标准，报告了4744名受试者，其中2008名为乙肝病毒阳性(B-肝细胞癌)组，2222名为丙型肝炎病毒阳性(C-肝细胞癌)组，514名为乙肝和丙型肝炎病毒阴性组(NBNC-肝癌)。Meta分析显示，乙型或丙型肝炎感染者的5年无瘤生存率低于非小细胞肝癌患者(OR：0.39，95%CI：0.28~0.53，P<；0.001；WMD：0.37，95%CI：0.22~0.64，P<；0.001)。与其他两组相比，NBNC-HCC组的5年总存活率有上升的趋势，尽管这些差异在统计学上并不显著。B-肝细胞癌和C-肝细胞癌患者的5年总生存率和无瘤生存率均无差异。接受肝细胞癌切除术的乙型或丙型肝炎血清学阳性患者与血清学阴性患者相比，预后较差。
The influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma (HCC) remains a matter of debate. This study is a meta-analysis of the available evidence. A literature search was performed to identify comparative studies reporting postoperative survival of HCC in different types of viral hepatitis. Pooled odds ratios (OR) and weighted mean differences (WMD with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model. Twenty studies matched the selection criteria and reported on 4744 subjects, of whom 2008 in the HBV-positive (B-HCC) group, 2222 in the HCV-positive (C-HCC) group, and 514 in the hepatitis B- and C-negative (NBNC-HCC). Meta-analysis showed that patients with HBV or HCV infection had a worse 5-year disease-free survival when compared to patients with NBNC-HCC (respectively: OR: 0.39, 95% CI: 0.28 to 0.53, P < 0.001; WMD: 0.37, 95% CI: 0.22 to 0.64, P < 0.001). There was a tendency toward higher 5-year overall survival rates in the NBNC-HCC group compared to those in the other two groups, although these differences were not statistically significant. Both the 5-year overall survival and disease-free survival were not different among the B-HCC and C-HCC groups. Patients with positive serology for hepatitis B or C undergoing resection for HCC had a poor prognosis compared to patients with negative serology.
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DOI：
10.1111/j.1440-1746.2006.04619.x
发表时间：
2007-11-01
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
2.6
作者：
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影响因子：
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作者：
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