Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.
Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.
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DOI：
10.1186/s13018-022-02980-2
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发表时间：
2022-02-19
影响因子：
2.6
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Shi X;Wu Y;Ni H;Li M;Zhang C;Qi B;Wei M;Wang T;Xu Y
目前的工作旨在收集关于抗生素负载硫酸钙（CS）作为种植体治疗慢性骨髓炎（COM）的根除率和相关术后并发症的可获得证据。检索了PubMed、EMBASE、Medline、Ovid和Cochrane等数据库，检索时间为起始日期至2021年11月。两位独立作者根据根治性清创联合抗生素CS治疗COM的有效性对相关研究进行了详细审查；作者还进行了数据提取和非随机研究方法学指数（未成年人）标准的质量评估。此外，临床疗效主要取决于对根除率和并发症的评估，所有提取的数据均通过STATA 16.0进行汇总分析。总共招募了16项研究，涉及917名患者（920个地点），总体根除率为92%。总体再手术率、总体再骨折率、总体伤口延迟愈合率和无菌伤口漏出率分别为9.0%、2.0%、20.0%和12.0%。此外，选择妥布霉素负载CS或万古霉素联合庆大霉素负载CS不影响COM患者的根除率和术后并发症发生率（全部）。纳入研究的总体质量尚可。我们的荟萃分析显示，使用含抗生素的CS治疗的COM的总根除率为92%。延迟愈合是最常见的术后并发症。选择妥布霉素负载CS或万古霉素联合庆大霉素负载CS对COM患者的根除率和术后并发症发生率均无影响。
Present work was aimed to gather accessible evidence on the eradication rates and related postoperative complications of antibiotic-loaded calcium sulfate (CS) as an implant in the treatment of chronic osteomyelitis (COM). Databases including PubMed, EMBASE, Medline, Ovid and Cochrane library were searched from their dates of initiation until November 2021. Two independent authors scrutinized the relevant studies based on the effectiveness of radical debridement combined with antibiotic-loaded CS for COM; data extraction and quality assessment of the Methodological Index for Non-Randomized Studies (MINORS) criteria were also performed by the authors. In addition, clinical efficacy mainly depended on the evaluation of eradication rates and complications, and all the extracted data are pooled and analyzed by STATA 16.0. A total of 16 studies with 917 patients (920 locations) were recruited, with an overall eradication rate of 92%. Moreover, the overall reoperation rate, overall refracture rate, overall delayed wound healing rate, and the rate of aseptic wound leakage were 9.0%, 2.0%, 20.0%, and 12.0%, respectively. Moreover, the choice of tobramycin-loaded CS or vancomycin combined with gentamicin-loaded CS did not affect the eradication rate, and the incidence of postoperative complications in COM patients (all ). The general quality of the included studies was fair. Our meta-analysis indicated that the overall eradication rate of COM treated with antibiotic-loaded CS was 92%. Delayed healing is the most common postoperative complication. The choice of tobramycin-loaded CS or vancomycin combined with gentamicin-loaded CS did not affect the eradication rate and the incidence of postoperative complications in COM patients.
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影响因子：
4.6
作者：
Kallala, R.;Haddad, F. S.
通讯作者：
Haddad, F. S.
影响因子：
4.6
作者：
Kallala R;Harris WE;Ibrahim M;Dipane M;McPherson E
通讯作者：
McPherson E
影响因子：
1
作者：
Gramlich, Y.;Walter, G.;Hoffmann, R.
通讯作者：
Hoffmann, R.
DOI：
10.1002/jor.24689
发表时间：
2020-10
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Cobb LH;McCabe EM;Priddy LB
通讯作者：
Priddy LB
影响因子：
--
作者：
Ferrando A;Part J;Baeza J
通讯作者：
Baeza J