The next addiction-causing drug class 4-quinazolinone derivatives: analyses of methaqualone analogs including recently discovered 2-methoxyqualone by different modes of mass spectrometry
The next addiction-causing drug class 4-quinazolinone derivatives: analyses of methaqualone analogs including recently discovered 2-methoxyqualone by different modes of mass spectrometry
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下一个成瘾药物4类-喹唑啉酮衍生物：通过不同的质谱模式分析甲喹酮类似物，包括最近发现的2-甲氧基喹酮
DOI：
10.1007/s11419-022-00631-z
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发表时间：
2022-06
影响因子：
2.2
通讯作者：
Koutaro Hasegawa
中科院分区：
文献类型：
--
作者：
Hongkun Yang;Yue Wang;Jinlei Liu;Shi Qiu;Jie Gu;Huiru Bai;Jun Li;Amin Wurita;Koutaro Hasegawa
目的甲喹酮、依他喹酮、2-甲氧基喹酮等4-喹唑啉酮类娱乐性药物的分析方法资料很少。本研究用气相色谱-串联质谱（GC - MS/MS）分析了不同碰撞能量下这些药物的产物离子谱。由于2-甲氧基喹酮是最近才在可疑片剂中发现的一种新型消毒药，本文通过不同类型的质谱仪器获得了更详细的数据，并对片剂中2-甲氧基喹酮的定量数据进行了验证。方法采用气相色谱-质谱联用、高分辨率超高效液相色谱-四极杆飞行时间质谱联用和液相色谱-串联质谱联用。结果三种不同碰撞能化合物的GC - MS/MS产物离子谱未见报道。它们对于初步鉴定未知化合物非常有用。如果有参考标准，最终的鉴定和定量可以通过测量产物离子谱和选择的反应监测模式很容易地通过GC - MS/MS实现。用这种方法对新的2-甲氧基醌进行了最终鉴定和定量。该化合物在片中的含量为69.8±0.5% （w/w）。对乙酰氨基酚和咖啡因在片剂中共存，浓度分别约为10%和5%。结论本文首次用GC - MS/MS方法得到了甲喹酮、依喹酮和2-甲氧基喹酮在不同碰撞能量下的产物离子谱。此外，本文首次详细描述了查获正品中2-甲氧基喹酮的定量。
PurposeThe information on analytical methods for 4-quinazolinone recreational drugs, such as methaqualone, etaqualone and 2-methoxyqualone, is almost scant. In this study, product ion spectra of gas chromatography−tandem mass spectrometry (GC−MS/MS) with different collision energies were presented for these drugs. Because 2-methoxyqualone is a new recreational drug discovered in dubious tablets very recently, much more detailed data obtained by different types of mass spectrometry instruments, and quantification data of 2-methoxyqualone in the tablet together with its validation were demonstrated.MethodsThe methods for analyses were GC−MS/MS, high-resolution ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry and liquid chromatography−tandem mass spectrometry.ResultsThe GC−MS/MS product ion spectra of the three compounds with different collision energies have not been reported before. They were very useful to tentatively identify unknown compounds. If a reference standard is available, the final identification and quantification can be achieved by measurements of product ion spectra and in selected reaction monitoring mode very easily by GC−MS/MS. The final identification and quantification for the new 2-methoxyqualone were performed in this way. The content of the compound was 69.8 ± 0.5% (w/w) in the tablet. Acetaminophen and caffeine coexisted in the tablet with approximate concentrations at 10 and 5%, respectively.ConclusionsIn this article, we have presented product ion spectra of methaqualone, etaqualone and 2-methoxyqualone at different collision energies by GC−MS/MS for the first time. In addition, this is the first paper to describe the details of quantification of 2-methoxyqualone in the authentic seized product.
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使用 GC-MS/MS 检测和定量人头发中的精神药物依喹酮。
影响因子：
1.5
作者：
Yang Hongkun;Wang Yue;Wurita Amin;Liu Jinlei;Dai Lina;Wei Junmei
通讯作者：
Wei Junmei
影响因子：
1.6
作者：
A. Grove;E. Rohwer;J. Laurens;B. Vorster
通讯作者：
A. Grove;E. Rohwer;J. Laurens;B. Vorster
DOI：
10.1186/s43141-021-00224-0
发表时间：
2021-08-21
期刊：
Journal, genetic engineering & biotechnology
影响因子：
--
作者：
Ghit A;Assal D;Al-Shami AS;Hussein DEE
通讯作者：
Hussein DEE
警方查获的包裹中发现了一种新型消遣性药物 2-甲氧基喹酮：初步报告
影响因子：
2.2
作者：
Hongkun Yang;Shuyun Wang;Haitao Qi;Jinlei Liu;Yue Wang;Jie Gu;Amin Wurita;Koutaro Hasegawa
通讯作者：
Koutaro Hasegawa
影响因子：
2.5
作者：
K. M. Woods
通讯作者：
K. M. Woods