Blebs in intracranial aneurysms: prevalence and general characteristics.
Blebs in intracranial aneurysms: prevalence and general characteristics.
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DOI：
10.1136/neurintsurg-2020-016274
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发表时间：
2021-03
影响因子：
4.8
通讯作者：
Cebral JR
中科院分区：
文献类型：
--
作者：
Salimi Ashkezari SF;Detmer FJ;Mut F;Chung BJ;Yu AK;Stapleton CJ;See AP;Amin-Hanjani S;Charbel FT;Rezai Jahromi B;Niemelä M;Frösen J;Zhou J;Maiti S;Robertson AM;Cebral JR
气泡是颅内动脉瘤（IAs）破裂的危险因素，但其患病率、分布、与临床因素的关系以及对动脉瘤易损性的原因和影响尚不清楚。通过3D血管造影图像对患者特异性血管重建，研究了270例手术患者的122个水泡。分析气泡的几何形状、在动脉瘤上的位置以及不同位置动脉瘤发生的频率。调查了性别、年龄、吸烟、高血压、激素治疗、牙齿感染和存在水泡之间的关系。在所有有气泡的动脉瘤中，77%为单个气泡，23%为多个气泡。只有6%的水泡在脖子上，46%在身体上，48%在穹顶上。含有气泡的动脉瘤比没有气泡的动脉瘤更大（p<0.0001），更长（p=0.0002），颈宽。在女性中，水泡存在与牙齿感染相关（p=0.0426），与激素治疗负相关（p=0.0426）。前、后交通动脉的动脉瘤含泡率高于颈内动脉。有高血压病史的患者有较大比例的动脉瘤伴水泡。然而，这些趋势在这个样本中没有达到显著性，气泡在IAs中很常见，大多数含有气泡的动脉瘤只有一个气泡。动脉瘤颈部的水泡是罕见的，但它们在身体和穹窿同样常见。牙内存在水泡与牙齿感染相关，与激素替代治疗负相关。
Blebs are rupture risk factors in intracranial aneurysms (IAs), but their prevalence, distribution, and associations with clinical factors as well as their causes and effects on aneurysm vulnerability remain unclear. A total of 122 blebs in 270 IAs selected for surgery were studied using patient-specific vascular reconstructions from 3D angiographic images. Bleb geometry, location on the aneurysm, and frequency of occurrence in aneurysms at different locations were analyzed. Associations between gender, age, smoking, hypertension, hormone therapy, dental infection, and presence of blebs were investigated. Of all aneurysms with blebs 77% had a single bleb and 23% had multiple blebs. Only 6% of blebs were at the neck, while 46% were in the body, and 48% in the dome. Aneurysms harboring blebs were larger (p<0.0001), more elongated (p=0.0002), and with wider necks than aneurysms without blebs. Bleb presence was associated with dental infection (p=0.0426), and negatively associated with hormone therapy (p=0.0426) in females. Anterior and posterior communicating arteries had larger percentages of aneurysms harboring blebs than internal carotid arteries. Patients with history of hypertension tended to have larger percent of aneurysms with blebs. However, these trends did not reach significance in this sample Blebs are common in IAs, and most aneurysms harboring blebs have a single bleb. Blebs in the aneurysm neck are rare, but they are equally common in the body and dome. Presence of blebs in IAs was associated with dental infection, and negatively associated with hormone replacement therapy.
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影响因子：
3.8
作者：
Robertson AM;Duan X;Aziz KM;Hill MR;Watkins SC;Cebral JR
通讯作者：
Cebral JR
影响因子：
8.3
作者：
Sonobe, Makoto;Yamazaki, Tomosato;Kikuchi, Haruhiko
通讯作者：
Kikuchi, Haruhiko
影响因子：
8.3
作者：
Lindgren, Antti E.;Koivisto, Timo;Frosen, Juhana
通讯作者：
Frosen, Juhana
DOI：
10.1055/s-0037-1598053
发表时间：
2017-09-01
影响因子：
1
作者：
Burkhardt, Jan-Karl;Fierstra, Jorn;Regli, Luca
通讯作者：
Regli, Luca
影响因子：
--
作者：
O'Shaughnessy, BA;Getch, CC;Batjer, HH
通讯作者：
Batjer, HH