Preparation and properties of calcium phosphate cement/small intestinal submucosa composite scaffold mimicking bone components and Haversian microstructure
Preparation and properties of calcium phosphate cement/small intestinal submucosa composite scaffold mimicking bone components and Haversian microstructure
复制标题
磷酸钙骨水泥/小肠粘膜下层复合支架的制备及性能模拟骨成分及哈弗微观结构
DOI：
10.1016/j.matlet.2017.10.065
复制
发表时间：
2018-02
影响因子：
3
通讯作者：
Luo Jing
中科院分区：
文献类型：
--
作者：
Bian Tierong;Zhao Kang;Meng Qingnan;Jiao Hua;Tang Yufei;Luo Jing
磷酸钙水泥(CPC)/小肠粘膜下层（SIS）复合支架通过巧妙堆叠仿生哈弗森基序（板层柱状基序）制备，可形成类似于天然骨骼哈弗森结构的结构。SIS含有丰富的胶原蛋白，CPC易于转化为羟基磷灰石进入体液，使得支架的成分与天然骨骼相似。支架的孔隙率和比表面积分别为32 ± 0.58%和26.749 ± 2.691 m2/m3。孔径范围主要为100 μm ~ 400 μm。大的比表面积和孔径不仅有利于细胞的附着、生长、迁移和血运重建，而且有利于支架的矿化。在10倍模拟体液浸泡6 h后，支架抗压强度约为27 MPa，是原支架抗压强度的3 倍。随着浸泡时间的延长，支架的抗压强度会增加，因此支架应该适合体内植入和骨重塑。
Calcium phosphate cement (CPC)/small intestinal submucosa (SIS) composite scaffold was prepared in this work by subtly stacking bio-inspired Haversian motifs (lamellar cylindrical motifs), which can form a structure similar to the Haversian microstructure in natural bones. SIS is rich in collagen and CPC can be easily transformed to hydroxyapatite into body fluids, making the components of the scaffold similar to natural bones. Porosity and specific surface area of the scaffold were 32 ± 0.58%, and 26.749 ± 2.691 m2/m3respectively. Pore size mainly ranges from 100 μm to 400 μm. The large specific surface area and the pore size are not only beneficial to cells attachment, growth, migration and revascularization, but also to the scaffold mineralization. After soaking for 6 h at 10× simulated body fluids, the compressive strength of the scaffold was about 27 MPa, 3 times more than that of the original scaffold. Thanks to the increasing compressive strength with holding the soaking time, the scaffold should be suitable for in vivo implanting and bone remodeling.
登录
查看更多内容
DOI：
10.1016/j.jmbbm.2009.02.001
发表时间：
2010
影响因子：
3.9
作者：
W. Lievers;Stephen D. Waldman;A. K. Pilkey
通讯作者：
W. Lievers;Stephen D. Waldman;A. K. Pilkey
影响因子：
2.9
作者：
Yang M;Wang J;Zhu Y;Mao C
通讯作者：
Mao C
影响因子：
2.4
作者：
CALER, WE;CARTER, DR
通讯作者：
CARTER, DR
影响因子：
4.1
作者：
W. Lievers;A. C. Petryshyn;A. Poljšak;S. Waldman;A. K. Pilkey
通讯作者：
W. Lievers;A. C. Petryshyn;A. Poljšak;S. Waldman;A. K. Pilkey
影响因子：
5.2
作者：
Kannaporn Pooput;N. Monmaturapoj;Jitlada Sansatsadeekul;S. Channasanon;A. Srion
通讯作者：
Kannaporn Pooput;N. Monmaturapoj;Jitlada Sansatsadeekul;S. Channasanon;A. Srion