The mRNA mobileome: challenges and opportunities for deciphering signals from the noise.

The mRNA mobileome: challenges and opportunities for deciphering signals from the noise.
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DOI:
10.1093/plcell/koad063
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发表时间:
2023-05-29
期刊:
The Plant cell
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其他
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生物体通信需要编码一条信息,该信息通过空间或时间发送到接收细胞,在那里该信息被解码以激活下游响应。定义什么是功能信号对于理解细胞间通讯至关重要。在这篇综述中,我们深入研究了长距离信使RNA(mRNA)运动领域中已知和未知的内容,并从信息论领域中汲取灵感,以提供一个定义功能性信号分子的视角。尽管许多研究支持数百至数千种mRNA通过植物维管系统的长距离运动,但这些转录本中只有少数与信号功能相关。由于我们目前缺乏对影响mRNA移动性的因素的了解,破译移动的mRNA是否在植物通讯中起作用一直是一个挑战。进一步深入了解有关移动的mRNA的性质未解决的问题,可以提供这些大分子的信号潜力的理解。
Organismal communication entails encoding a message that is sent over space or time to a recipient cell, where that message is decoded to activate a downstream response. Defining what qualifies as a functional signal is essential for understanding intercellular communication. In this review, we delve into what is known and unknown in the field of long-distance messenger RNA (mRNA) movement and draw inspiration from the field of information theory to provide a perspective on what defines a functional signaling molecule. Although numerous studies support the long-distance movement of hundreds to thousands of mRNAs through the plant vascular system, only a small handful of these transcripts have been associated with signaling functions. Deciphering whether mobile mRNAs generally serve a role in plant communication has been challenging, due to our current lack of understanding regarding the factors that influence mRNA mobility. Further insight into unsolved questions regarding the nature of mobile mRNAs could provide an understanding of the signaling potential of these macromolecules.
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