Message in a Bubble: Shuttling Small RNAs and Proteins Between Cells and Interacting Organisms Using Extracellular Vesicles.

Message in a Bubble: Shuttling Small RNAs and Proteins Between Cells and Interacting Organisms Using Extracellular Vesicles.
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气泡中的消息:使用细胞外囊泡在细胞和相互作用的生物之间穿梭小RNA和蛋白质。

DOI:
10.1146/annurev-arplant-081720-010616
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发表时间:
2021-06-17
影响因子:
23.9
通讯作者:
Jin H
Jin H
中科院分区:
生物学1区
文献类型:
--
作者:
Cai Q;He B;Wang S;Fletcher S;Niu D;Mitter N;Birch PRJ;Jin H

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植物细胞和相互作用的微生物之间的通讯需要分泌和吸收功能分子到细胞外环境和从细胞外环境,是植物和它们的病原体的生存所必需的。细胞外囊泡是一种由脂质双层包裹的微球,可将RNA、蛋白质和代谢产物从供体细胞运送到受体细胞,并参与许多细胞过程。新的证据表明,植物和微生物EV在宿主和相互作用的微生物之间的跨王国分子交换中发挥重要作用,以调节宿主免疫力和病原体毒力。最近的研究表明,植物EV作为一种防御系统,通过包裹和递送小RNA(sRNA)到病原体中,从而介导跨物种和跨王国的RNA干扰,以沉默毒力相关基因。本文综述了植物和微生物EV及其在宿主和病原体之间转运调控分子,特别是sRNA的最新进展。EV生物合成和分泌也进行了讨论,因为EV功能依赖于这些重要的过程。
Communication between plant cells and interacting microorganisms requires the secretion and uptake of functional molecules to and from the extracellular environment and is essential for the survival of both plants and their pathogens. Extracellular vesicles (EVs) are lipid bilayer–enclosed spheres that deliver RNA, protein, and metabolite cargos from donor to recipient cells and participate in many cellular processes. Emerging evidence has shown that both plant and microbial EVs play important roles in cross-kingdom molecular exchange between hosts and interacting microbes to modulate host immunity and pathogen virulence. Recent studies revealed that plant EVs function as a defense system by encasing and delivering small RNAs (sRNAs) into pathogens, thereby mediating cross-species and cross-kingdom RNA interference to silence virulence-related genes. This review focuses on the latest advances in our understanding of plant and microbial EVs and their roles in transporting regulatory molecules, especially sRNAs, between hosts and pathogens. EV biogenesis and secretion are also discussed, as EV function relies on these important processes.
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