Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET.
Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET.
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DOI：
10.1186/s13195-021-00776-w
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发表时间：
2021-02-08
期刊：
影响因子：
--
通讯作者：
Possin KL
中科院分区：
文献类型：
--
作者：
Tsoy E;Strom A;Iaccarino L;Erlhoff SJ;Goode CA;Rodriguez AM;Rabinovici GD;Miller BL;Kramer JH;Rankin KP;La Joie R;Possin KL
β-淀粉样蛋白(Aβ)和tau正电子发射断层扫描检测活人中定义阿尔茨海默病(AD)的病理变化。对Aβ和tau负荷敏感的认知措施可能有助于简化AD生物标记物验证性测试的病例识别。我们使用Logistic回归模型检验了轻度认知损害或痴呆患者(N=14 0；43 Aβ-，97 Aβ+)中基于脑健康评估片的认知测量与二分式Aβ-PET状态的相关性。我们还利用体素回归分析，对60名患有轻度认知障碍或痴呆症的β+患者进行了体素回归分析，研究了生物透明质酸测试与tau-PET信号的区域模式之间的关系。偏爱(联想记忆)、匹配(执行功能和速度)和日常认知量表得分与Aβ阳性显著相关(曲线下面积=0.75[95%CI 0.6 6~0.85])。在MCI和痴呆症患者的一个子样本中，我们发现在最喜欢的近侧颞区、匹配的额顶区和线条定向(视觉空间技能)的枕顶区与tau-PET信号显著相关。BHA测定与A-β和活体局部tau显着相关，可用于临床诊断疑似AD患者。网上版载有补充材料，可在10.1186/s13195-021-00776-w查阅。
β-amyloid (Aβ) and tau positron emission tomography (PET) detect the pathological changes that define Alzheimer’s disease (AD) in living people. Cognitive measures sensitive to Aβ and tau burden may help streamline identification of cases for confirmatory AD biomarker testing. We examined the association of Brain Health Assessment (BHA) tablet-based cognitive measures with dichotomized Aβ -PET status using logistic regression models in individuals with mild cognitive impairment (MCI) or dementia (N = 140; 43 Aβ-, 97 Aβ+). We also investigated the relationship between the BHA tests and regional patterns of tau-PET signal using voxel-wise regression analyses in a subsample of 60 Aβ+ individuals with MCI or dementia. Favorites (associative memory), Match (executive functions and speed), and Everyday Cognition Scale scores were significantly associated with Aβ positivity (area under the curve [AUC] = 0.75 [95% CI 0.66–0.85]). We found significant associations with tau-PET signal in mesial temporal regions for Favorites, frontoparietal regions for Match, and occipitoparietal regions for Line Orientation (visuospatial skills) in a subsample of individuals with MCI and dementia. The BHA measures are significantly associated with both Aβ and regional tau in vivo imaging markers and could be used for the identification of patients with suspected AD pathology in clinical practice. The online version contains supplementary material available at 10.1186/s13195-021-00776-w.
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DOI：
10.1038/s41582-018-0079-7
发表时间：
2018-11
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Hampel H;O'Bryant SE;Molinuevo JL;Zetterberg H;Masters CL;Lista S;Kiddle SJ;Batrla R;Blennow K
通讯作者：
Blennow K
影响因子：
9
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影响因子：
9
作者：
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通讯作者：
Wang, Pei-Ning
DOI：
10.1016/j.dadm.2019.09.001
发表时间：
2019-12-01
影响因子：
5.3
作者：
Maserejian, Nancy;Bian, Shijia;Gao, Feng
通讯作者：
Gao, Feng
影响因子：
11.2
作者：
Josephs KA;Martin PR;Botha H;Schwarz CG;Duffy JR;Clark HM;Machulda MM;Graff-Radford J;Weigand SD;Senjem ML;Utianski RL;Drubach DA;Boeve BF;Jones DT;Knopman DS;Petersen RC;Jack CR Jr;Lowe VJ;Whitwell JL
通讯作者：
Whitwell JL