Is Interleukin 1α a Luteotropic or Luteolytic Agent in Cattle
Is Interleukin 1α a Luteotropic or Luteolytic Agent in Cattle
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白细胞介素 1α 是牛的促黄体素或黄体分解剂吗
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
K. Okuda
中科院分区：
文献类型：
--
作者：
D. Skarżyński;M. Majewska;Mamamdou Moussa Bah;Joanna Hapunik;K. Piotrowska;K. Okuda
细胞因子被认为调节牛子宫内膜中前列腺素（PG）的分泌。然而，关于白细胞介素-1 α（IL-1A）对PG分泌的作用还没有达成共识。本研究的目的是检测IL-1A对体外基础和干扰素-t（IFN-γ）调节的PG分泌的影响，以及其对体内PG分泌、孕酮（P-4）分泌和黄体（CL）寿命的影响。用IL 1A（10 ng/ml）、IFNT（30 ng/ml）或IL 1A与IFN的组合刺激牛子宫内膜（发情周期或早期妊娠的第16 - 17天）的外植体。IL 1A单独强烈刺激黄体PGE 2分泌的子宫内膜组织的怀孕和非怀孕的奶牛。IL 1A还刺激黄体晚期的溶黄体PGF 2 α输出。IFN-γ增强IL-1A对PGE2分泌的刺激作用。在体内实验中，在周期的第16天将不同剂量（0.001 - 10 mg/只动物）的盐水或IL 1A施加到子宫腔。只有最高剂量的IL 1A引起PGF 2 a分泌的暂时增加，而对P4分泌和CL寿命没有影响。应用0.1和1mg IL 1A可刺激P4和PGE2分泌，延长CL寿命。虽然IL 1A在体外可刺激动情周期中溶黄体的PGF 2 a分泌，但在体内仅作为促黄体因子发挥作用。IL 1A增加促黄体PGE 2和P 4的分泌，抑制自发性黄体溶解。这些促黄体作用可能导致母牛在发情周期和妊娠早期的适当黄体发育和功能。
Cytokines are thought to regulate prostaglandin (PG) secretion in the bovine endometrium. However, there is no consensus about the role of interleukin-1 a (IL1A) on PG secretion. The objective of this study was to examine the influence of IL1A on basal and interferon- t (IFNT)-regulated PG in vitro secretion, as well its effects on PG secretion, progesterone (P 4 ) output, and corpus luteum (CL) in vivo lifespan. Explants of bovine endometrium (days 16–17 of the estrous cycle or early pregnancy) were stimulated with IL1A (10 ng/ml), IFNT (30 ng/ml), or IL1A combined with IFN. IL1A alone strongly stimulated luteotrophic PGE 2 secretion by endometrial tissues of both pregnant and nonpregnant cows. IL1A also stimulated luteolytic PGF 2 a output in the late luteal phase. IFNTaugmented the stimulatory effect of IL1A on PGE 2 secretion. In an in vivo experiment, saline or IL1A at different doses (0.001–10 m g/per animal) was applied to the uterine lumen on day 16 of the cycle. Only the highest dose of IL1A caused a temporal increase in PGF 2 a secretion, while it had no effect on P 4 secretion or CL lifespan. Application of 0.1 and 1 m g IL1A stimulated P 4 and PGE 2 output and prolonged the CL lifespan. Although IL1A may stimulate in vitro luteolytic PGF 2 a secretion during the estrous cycle, it onlyacts as a luteotrophic factor in vivo . IL1A increased luteotrophic PGE 2 and P 4 output, inhibiting spontaneous luteolysis. These luteotrophic effects may result in appropriate luteal development and function in cows during the estrous cycle and early pregnancy.
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牛滋养层蛋白-1 复合物可改变子宫内膜蛋白和前列腺素分泌，并在体外诱导前列腺素合成的细胞内抑制剂。
DOI：
10.1530/jrf.0.0870421
发表时间：
1989
期刊：
Journal of reproduction and fertility
影响因子：
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作者：
Helmer,SD;Gross,TS;Newton,GR;Hansen,PJ;Thatcher,WW
通讯作者：
Thatcher,WW
DOI：
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发表时间：
2004
期刊：
--
影响因子：
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作者：
Charles A. Dinarello;Vol.;Sheldon M. Wolff
通讯作者：
Charles A. Dinarello;Vol.;Sheldon M. Wolff
DOI：
10.1016/j.anireprosci.2004.04.014
发表时间：
2004-07-05
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Spencer, Thomas E;Bazer, Fuller W
通讯作者：
Bazer, Fuller W
影响因子：
1.9
作者：
Spencer, Thomas E.;Johnson, Greg A.;Palmarini, Massimo
通讯作者：
Palmarini, Massimo