Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning.
Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning.
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DOI：
10.1016/j.neuron.2013.08.008
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发表时间：
2013-10-16
期刊：
影响因子：
16.2
通讯作者：
Schoenbaum G
中科院分区：
文献类型：
--
作者：
Takahashi YK;Chang CY;Lucantonio F;Haney RZ;Berg BA;Yau HJ;Bonci A;Schoenbaum G
Imagination, defined as the ability to interpret reality in ways that diverge from past experience, is fundamental to adaptive behavior. This can be seen at a simple level in our capacity to predict novel outcomes in new situations. The ability to anticipate outcomes never before received can also influence learning if those imagined outcomes are not received. The orbitofrontal cortex is a key candidate for where the process of imagining likely outcomes occurs; however its precise role in generating these estimates and applying them to learning remain open questions. Here we address these questions by showing that single-unit activity in orbitofrontal cortex reflects novel outcome estimates. The strength of these neural correlates predicted both behavior and learning, learning which was abolished by temporally-specific inhibition of orbitofrontal neurons. These results are consistent with the proposal that the orbitofrontal cortex is critical for integrating information to imagine future outcomes.
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DOI：
10.1523/jneurosci.4920-12.2013
发表时间：
2013-01-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Luk CH;Wallis JD
通讯作者：
Wallis JD
影响因子：
64.8
作者：
Burke, Kathryn A.;Franz, Theresa M.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey
DOI：
10.1037/0097-7403.1.4.355
发表时间：
1975-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
HOLLAND, PC;RESCORLA, RA
通讯作者：
RESCORLA, RA
DOI：
10.1523/jneurosci.3758-08.2009
发表时间：
2009-01-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Johnson AW;Gallagher M;Holland PC
通讯作者：
Holland PC
影响因子：
16.2
作者：
Abe H;Lee D
通讯作者：
Lee D