Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration.
Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration.
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DOI：
10.1038/s41467-020-19660-6
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发表时间：
2020-11-25
影响因子：
16.6
通讯作者：
Rogers JA
中科院分区：
文献类型：
--
作者：
Choi YS;Hsueh YY;Koo J;Yang Q;Avila R;Hu B;Xie Z;Lee G;Ning Z;Liu C;Xu Y;Lee YJ;Zhao W;Fang J;Deng Y;Lee SM;Vázquez-Guardado A;Stepien I;Yan Y;Song JW;Haney C;Oh YS;Liu W;Yoon HJ;Banks A;MacEwan MR;Ameer GA;Ray WZ;Huang Y;Xie T;Franz CK;Li S;Rogers JA
生物可吸收电子刺激器作为不寻常的治疗平台（即生物电子药物），用于治疗疾病状态、加速伤口愈合过程和消除感染，引起了越来越多的兴趣。在这里，我们展示了先进的材料，支持在临床相关时间范围内在这些系统中进行操作，最终无害地生物再吸收为无残留的良性产品，从而消除了手术提取的需要。我们的研究结果通过实现符合临床需求的寿命来克服生物可吸收电子设备的关键挑战。这些设备利用生物可吸收动态共价聚合物，促进其自身和其他表面的紧密粘合，作为无线电子元件的柔软、弹性基材和封装涂层。我们描述了这种聚合物的基本特征和化学设计考虑因素，以及其组成材料的生物相容性。在具有优化无线设计的设备中，这些聚合物能够在周围神经损伤的大鼠模型中作为远端刺激器实现稳定、长寿命的操作，从而展示了可编程长期电刺激在维持肌肉感受性和增强功能恢复方面的潜力。生物可吸收电子刺激器可以向啮齿类动物提供电刺激，以增强神经损伤后功能性肌肉的恢复。在这里，作者提出了一种生物可吸收的动态共价聚合物，它能够使这种类型的柔软、可拉伸的装置可靠、长寿命地运行。
Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery. Bioresorbable electronic stimulators can deliver electrical stimulation in rodents to enhance functional muscle recovery after nerve injury. Here, the authors present a bioresorbable dynamic covalent polymer that enables reliable, long-lived operation of soft, stretchable devices of this type.
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影响因子：
19
作者：
Choi, Yeon Sik;Koo, Jahyun;Rogers, John A.
通讯作者：
Rogers, John A.
影响因子：
2.7
作者：
Jin, Jenny;Park, Michelle;Kuo, Alfred C.
通讯作者：
Kuo, Alfred C.
影响因子：
15
作者：
Capelot, Mathieu;Montarnal, Damien;Leibler, Ludwik
通讯作者：
Leibler, Ludwik
影响因子：
10.8
作者：
Hwang, Suk-Won;Lee, Chi Hwan;Rogers, John A.
通讯作者：
Rogers, John A.
DOI：
10.1097/00002060-199803000-00009
发表时间：
1998-03-01
影响因子：
3
作者：
Dumitru, D;King, JC
通讯作者：
King, JC