Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates.
Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates.
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DOI：
10.1038/bjc.2011.168
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发表时间：
2011-06-28
影响因子：
8.8
通讯作者：
Robinson, D.
中科院分区：
文献类型：
--
作者：
Moller, H.;Richards, S.;Hanchett, N.;Riaz, S. P.;Luechtenborg, M.;Holmberg, L.;Robinson, D.
有人认为，英格兰的癌症登记过于依赖于对死亡证明信息的处理，因此，英格兰报告的癌症存活率统计数据存在系统性偏差，而且过低。我们将2001-2007年期间结直肠癌、肺癌和乳腺癌患者的常规癌症登记记录与医院事件统计（HES）数据库中的信息联系起来。基于与HES数据库的记录链接，确定了癌症登记中缺失的记录，并修订了诊断日期。研究了这些翻修对估计生存时间和生存1年或以上患者比例的影响。使用在癌症登记中不存在但在HES数据中存在的具有相关诊断代码和相关手术代码的病例来估计（a）癌症登记的完整性。使用从两个数据源计算的生存时间差异来估计（B）癌症登记中记录的生存时间的可能误差程度。最后，我们结合（a）和（B）来估计（c）1年累积生存率估计值的差异。在英国癌症登记处，病例确定的完整性很高，约为98- 99%。使用HES数据，结直肠癌、肺癌和乳腺癌登记数量分别增加了1.9%、0.4%和2.0%。大约5-6%的快速致命癌症登记的生存时间延长了一个月以上，近3%的快速致命乳腺癌记录延长了一年以上。由此产生的对1年生存率估计值的影响很小，结直肠癌、肺癌和乳腺癌分别为1.0、0.8和0.4个百分点。英语癌症登记数据不能被认为不适合癌症生存分析。然而，研究者应该对国际癌症生存研究中的数据质量和错误来源保持批判的态度。
It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low. We have linked routine cancer registration records for colorectal, lung, and breast cancer patients with information from the Hospital Episode Statistics (HES) database for the period 2001–2007. Based on record linkage with the HES database, records missing in the cancer register were identified, and dates of diagnosis were revised. The effects of those revisions on the estimated survival time and proportion of patients surviving for 1 year or more were studied. Cases that were absent in the cancer register and present in the HES data with a relevant diagnosis code and a relevant surgery code were used to estimate (a) the completeness of the cancer register. Differences in survival times calculated from the two data sources were used to estimate (b) the possible extent of error in the recorded survival time in the cancer register. Finally, we combined (a) and (b) to estimate (c) the resulting differences in 1-year cumulative survival estimates. Completeness of case ascertainment in English cancer registries is high, around 98–99%. Using HES data added 1.9%, 0.4% and 2.0% to the number of colorectal, lung, and breast cancer registrations, respectively. Around 5–6% of rapidly fatal cancer registrations had survival time extended by more than a month, and almost 3% of rapidly fatal breast cancer records were extended by more than a year. The resulting impact on estimates of 1-year survival was small, amounting to 1.0, 0.8, and 0.4 percentage points for colorectal, lung, and breast cancer, respectively. English cancer registration data cannot be dismissed as unfit for the purpose of cancer survival analysis. However, investigators should retain a critical attitude to data quality and sources of error in international cancer survival studies.
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影响因子：
8.4
作者：
Robinson, David;Sankila, Risto;Moller, Henrik
通讯作者：
Moller, Henrik
影响因子：
10
作者：
Holmberg, Lars;Sandin, Fredrik;Moller, Henrik
通讯作者：
Moller, Henrik
影响因子：
8.4
作者：
Larsen, Inger Kristin;Smastuen, Milada;Moller, Bjorn
通讯作者：
Moller, Bjorn
影响因子：
8.8
作者：
Bullard J;Coleman MP;Robinson D;Lutz JM;Bell J;Peto J
通讯作者：
Peto J
影响因子：
6.4
作者：
Moller, Henrik;Sandin, Fredrik;Holmberg, Lars
通讯作者：
Holmberg, Lars