Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung's Disease.
Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung's Disease.
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DOI：
10.1002/mabi.201400473
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发表时间：
2015-05
影响因子：
4.6
通讯作者：
Carrier, Rebecca L.
中科院分区：
文献类型：
--
作者：
Yildiz, Hasan M.;Carlson, Taylor L.;Goldstein, Allan M.;Carrier, Rebecca L.
粘液在肠上皮上形成保护性水凝胶层，对颗粒物的摄取和微生物入侵提供选择性和坚固的屏障。疾病可以改变粘液的产生和组成，从而潜在地改变粘膜屏障特性。先天性巨结肠是一种神经系统发育异常，常并发肠道感染。在HD动物模型（内皮素受体B突变小鼠）中对结肠粘液屏障特性的研究显示，相对于野生型，微球（被动）和微生物（主动）转运速率显著降低（在近端结肠粘液中分别为7倍和3.6倍）。运输差异在神经节和无神经节结肠段都很明显，这与手术切除无神经节结肠段后发生先天性巨结肠相关性小肠结肠炎的风险一致。旨在改变结肠粘液屏障特性的治疗方法的发展可以被探索用于预防先天性巨结肠症中小肠结肠炎的发作。
Mucus forms a protective hydrogel layer over the intestinal epithelium, presenting a selective and robust barrier to the uptake of particulates and microbe invasion. Disease can alter mucus production and composition, thus potentially modifying mucosal barrier properties. Hirschsprung’s disease (HD) is a developmental abnormality of the nervous system often complicated by intestinal infection. An investigation of colonic mucus barrier properties in an HD animal model, endothelin receptor B mutant mice, revealed significantly reduced microsphere (passive) and microbe (active) transport rates (7-fold and 3.6-fold, respectively, in proximal colonic mucus) relative to wild-type. Transport differences were evident in both the ganglionic and aganglionic colon segments, in agreement with the risk of Hirschsprung’s disease-associated enterocolitis after surgery to remove aganglionic colon segments. The development of therapies aimed at altering colonic mucus barrier properties could be explored towards preventing the onset of enterocolitis in Hirschsprung’s disease.
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影响因子：
3.7
作者：
Pontier-Bres R;Prodon F;Munro P;Rampal P;Lemichez E;Peyron JF;Czerucka D
通讯作者：
Czerucka D
影响因子：
2.9
作者：
Scaldaferri, Franco;Pizzoferrato, Marco;Gasbarrini, Antonio
通讯作者：
Gasbarrini, Antonio
影响因子：
3
作者：
Sbalzarini, IF;Koumoutsakos, P
通讯作者：
Koumoutsakos, P
影响因子：
5.4
作者：
Hansson GC
通讯作者：
Hansson GC
DOI：
10.1073/pnas.0636277100
发表时间：
2003-04-01
影响因子：
11.1
作者：
Suh, J;Wirtz, D;Hanes, J
通讯作者：
Hanes, J