Childhood maltreatment and social anxiety disorder: implications for symptom severity and response to pharmacotherapy.
Childhood maltreatment and social anxiety disorder: implications for symptom severity and response to pharmacotherapy.
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DOI：
10.1002/da.20909
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发表时间：
2012-02
影响因子：
7.4
通讯作者：
Liebowitz, Michael R.
中科院分区：
文献类型：
--
作者：
Bruce, Laura C.;Heimberg, Richard G.;Blanco, Carlos;Schneier, Franklin R.;Liebowitz, Michael R.
儿童期虐待与社交焦虑障碍（SAD）成人的症状严重程度、生活质量下降和功能受损有关。没有研究调查儿童期虐待如何影响这一人群的药物治疗结果，尽管有证据表明这种联系在抑郁症中。目前的研究复制了以前的工作中SAD儿童虐待，并检查其对药物治疗的影响。156名寻求SAD治疗的人完成了儿童创伤问卷，该问卷测量了各种类型的虐待和忽视，沿着症状严重程度，生活质量和残疾。分析了参加帕罗西汀试验的患者子集（N=127）的数据，以评估儿童期虐待对自然减员和治疗反应的影响。除了性虐待和身体虐待，所有类型的虐待都与更严重的症状有关。情感虐待和忽视与更大的残疾有关，情感虐待、情感忽视和身体虐待与生活质量下降有关。情感虐待显着预测磨损。情绪虐待互动的时间表明，对于那些坚持到底的人来说，情绪虐待对社交焦虑严重程度的影响随着时间的推移显着减弱。情感虐待与SAD患者的功能障碍联系最紧密，尽管焦虑文献倾向于关注性虐待和身体虐待的影响。此外，报告情绪虐待的人更有可能从药物治疗中退出，但那些坚持治疗的人与那些没有这种历史的人表现出相似的结果。
Childhood maltreatment has been associated with symptom severity, reduced quality of life, and impaired functioning in adults with social anxiety disorder (SAD). No study has investigated how childhood maltreatment impacts pharmacotherapy outcomes in this population, despite evidence for such a link in depression. The current study replicates previous work on childhood maltreatment within SAD and examines its impact on response to pharmacotherapy. 156 individuals seeking treatment for SAD completed the Childhood Trauma Questionnaire, which measures various types of abuse and neglect, along with measures of symptom severity, quality of life, and disability. Data from a subset of patients enrolled in a paroxetine trial (N=127) were analyzed to gauge the impact of childhood maltreatment on attrition and treatment response. All types of maltreatment except for sexual abuse and physical abuse were related to greater symptom severity. Emotional abuse and neglect were related to greater disability, and emotional abuse, emotional neglect, and physical abuse were related to decreased quality of life. Emotional abuse significantly predicted attrition. A time by emotional abuse interaction suggests that for those who stayed the course, the impact of emotional abuse on severity of social anxiety weakened significantly over time. Emotional maltreatment was most strongly linked to dysfunction in SAD, despite a tendency in the anxiety literature to focus on the effects of sexual and physical abuse. Additionally, individuals reporting emotional abuse were more likely to dropout from pharmacotherapy, but those who stayed the course displayed similar outcomes to those without such a history.
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影响因子：
6.9
作者：
Lee, S.;Guo, W. J.;Tsang, A.;He, Y. L.;Huang, Y. Q.;Zhang, M. Y.;Liu, Z. R.;Shen, Y. C.;Kessler, R. C.
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10.1007/s10862-009-9161-1
发表时间：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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