Ovariectomy shortens the life span of female mice.
Ovariectomy shortens the life span of female mice.
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DOI：
10.18632/oncotarget.2984
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发表时间：
2015-05-10
期刊：
影响因子：
--
通讯作者：
Maggi A
中科院分区：
文献类型：
--
作者：
Benedusi V;Martini E;Kallikourdis M;Villa A;Meda C;Maggi A
这项研究表明，卵巢活动不足对雌性小鼠的寿命有负面影响。通过定量分析炎症级联反应中编码蛋白质的mRNAs，分析了这种现象在多大程度上与雌激素的抗炎作用有关。结果表明，卵巢摘除后7个月小鼠肝脏、脂肪组织和主动脉组织中肿瘤坏死因子α、IL-1β、单核细胞趋化蛋白-1、巨噬细胞趋化蛋白-2和IL-6mRNA的含量均增加，并且这种增加的基础炎症反应随着年龄的增长而维持。相比之下，在假手术小鼠中，炎症基因表达的程度与年龄成正比。因此，在22个月时，假手术组的大多数炎症参数都高于去卵巢组。这些观察结果使我们提出，OVX小鼠寿命下降可能是由于代谢器官炎症基础状态的加速，这可能是由于缺乏雌激素介导的抗炎活性和性腺失去对能量代谢的控制所致。
This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in sham-operated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
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影响因子：
7.2
作者：
Parker WH;Broder MS;Chang E;Feskanich D;Farquhar C;Liu Z;Shoupe D;Berek JS;Hankinson S;Manson JE
通讯作者：
Manson JE
DOI：
10.1530/jrf.0.0140113
发表时间：
1967-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
ASDELL, SA;DOORNENBAL, H;SPERLING, GA
通讯作者：
SPERLING, GA
影响因子：
29
作者：
Della Torre, Sara;Rando, Gianpaolo;Maggi, Adriana
通讯作者：
Maggi, Adriana
影响因子：
2.8
作者：
Jouyandeh Z;Nayebzadeh F;Qorbani M;Asadi M
通讯作者：
Asadi M
影响因子：
7.8
作者：
Judd ET;Wessels FJ;Drewry MD;Grove M;Wright K;Hahn DA;Hatle JD
通讯作者：
Hatle JD