Chorioamnionitis, IL-17A, and fetal origins of neurologic disease.
Chorioamnionitis, IL-17A, and fetal origins of neurologic disease.
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DOI：
10.1111/aji.12803
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Wynn JL
中科院分区：
文献类型：
--
作者：
Lawrence SM;Wynn JL
疾病控制和预防中心估计，每323名婴儿中就有一名患有脑瘫。脑性瘫痪与宫内感染和炎症高度相关，尽管在新生儿重症监护方面取得了重大进展，包括改进的呼吸机技术、表面活性物质治疗、产妇类固醇给药和产期经验性抗菌药物的使用，但脑瘫的发病率在过去几十年一直保持不变。最近我们对感染和炎症免疫反应的了解取得了进展，发现细胞因子IL-17A是早期促炎介质的重要组成部分，导致与神经功能损害相关的脑损伤。值得注意的是，母亲对宫内炎症和感染的炎症反应也可能导致后代的神经疾病，这种情况通常在儿童和/或成年早期临床上表现得很明显。这篇综述详细介绍了IL-17A在胎儿和母体前炎症反应中的作用，这些反应导致胎儿脑损伤和神经后遗症，包括脑性瘫痪。关于母体炎症反应在儿童和成人神经系统疾病发展中的作用的最新发现，如自闭症、精神分裂症和多发性硬化症，也将被强调。
The Centers for Disease Control and Prevention estimate that 1 in 323 infants have cerebral palsy. Highly correlated to intrauterine infection and inflammation, the incidence of cerebral palsy has remained constant over the last few decades despite significant advances in neonatal intensive care including improved ventilator techniques, surfactant therapy, maternal steroid administration, and use of intrapartum empiric antimicrobials. Recent advances in our understanding of immune responses to infection and inflammation have identified the cytokine IL-17A as a crucial component of early pro-inflammatory mediators that cause brain injury associated with neurologic impairment. Remarkably, maternal inflammatory responses to in utero inflammation and infection can also lead to potentially debilitating neurologic conditions in the offspring, which often become clinically apparent during childhood and/or early adulthood. This review details the role of IL-17A in fetal and maternal proinflammatory responses that lead to fetal brain injury and neurologic sequelae, including cerebral palsy. Recent findings regarding the role of maternal inflammatory responses in the development of childhood and adult neurologic conditions, such as autism, schizophrenia, and multiple sclerosis, will also be highlighted.
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DOI：
10.1111/aji.12623
发表时间：
2017-03
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Anders AP;Gaddy JA;Doster RS;Aronoff DM
通讯作者：
Aronoff DM
影响因子：
9.3
作者：
Albertsson AM;Bi D;Duan L;Zhang X;Leavenworth JW;Qiao L;Zhu C;Cardell S;Cantor H;Hagberg H;Mallard C;Wang X
通讯作者：
Wang X
影响因子：
5.1
作者：
Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
影响因子：
11.2
作者：
Chau, Vann;Poskitt, Kenneth J.;Miller, Steven P.
通讯作者：
Miller, Steven P.
影响因子：
4.2
作者：
Burd I;Bentz AI;Chai J;Gonzalez J;Monnerie H;Le Roux PD;Cohen AS;Yudkoff M;Elovitz MA
通讯作者：
Elovitz MA