Impact of TOF on Brain PET With Short-Lived (11)C-Labeled Tracers Among Suspected Patients With AD/PD: Using Hybrid PET/MRI.
Impact of TOF on Brain PET With Short-Lived (11)C-Labeled Tracers Among Suspected Patients With AD/PD: Using Hybrid PET/MRI.
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TOF 对疑似 AD/PD 患者中使用短效 11C 标记示踪剂进行脑部 PET 的影响：使用混合 PET/MRI
DOI：
10.3389/fmed.2022.823292
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发表时间：
2022
影响因子：
3.9
通讯作者：
Lan X
中科院分区：
文献类型：
--
作者：
Wimalarathne DDN;Ruan W;Sun X;Liu F;Gai Y;Liu Q;Hu F;Lan X
探讨飞行时间（TOF）重建对疑似阿尔茨海默病和帕金森病（AD/PD）患者PET磁共振（PET/MR）脑图像中使用短寿命11 C标记示踪剂的脑PET的影响。本研究回顾性纳入了接受11 C-2-β-甲氧羰基-3-B-（4-氟苯基）托烷（11 C-CFT）和2-（4-N-[11 C]甲氨基苯基）-6-羟基苯并噻唑（11 C-Pi B）PET/MRI的患者。使用和不使用TOF重建算法重建每个PET LIST模式数据。测量尾状核（CN）、壳核（PU）和全脑（WB）的标准摄取值（SUV）。TOF和非TOF SUV采用配对t检验进行评估。应用标准公式测量对比度、信噪比（SNR）和SUV的相对平均差异百分比（% RAD-SUV）。共纳入75例患者，11 C-CFT（n = 41）中位年龄（岁）和体重指数（BMI-kg/m2）分别为60. 2 ± 10. 9岁和23. 9 ± 3. 7 kg/m2，11 C-PiB（n = 34）中位年龄（岁）和体重指数（BMI-kg/m2）分别为62. 2 ± 6. 8岁和24. 7 ± 2. 9 kg/m2。对于两种11 C标记的放射性示踪剂，与非TOF重建相比，TOF中CN和PU中观察到更高的平均SUV和阳性% RAD-SUV。对于两种11 C标记的放射性示踪剂，CN和PU的SUV平均值差异显著（p < 0.05）。CN和PU中11 C-CFT和CN中11 C-PiB的SUVmax显著增加，但PU中不增加。两种11 C标记的放射性示踪剂在PU中观察到显著的对比度增强，而SNR增益在PU中显著，仅在TOF重建中对11 C-PiB。在CN和PU之间的11 C标记示踪剂中，飞行时间导致比非TOF更好的信号与噪声权衡，从而改善SUV、对比度和SNR，这对于降低注入的辐射剂量是有价值的。改善的时间分辨率有助于短寿命11 C标记示踪剂的快速衰减速率，并且它缩短了扫描时间，增加了患者的舒适度，并减少了AD/PD患者的运动伪影。但由于联合TOF算法对不同脑区的SUVmax、对比度和信噪比的影响不同，因此在进行定量分析时应谨慎使用。
To explore the impact of the time-of-flight (TOF) reconstruction on brain PET with short-lived 11C-labeled tracers in PET magnetic resonance (PET/MR) brain images among suspected patients with Alzheimer's and Parkinson's disease (AD/PD). Patients who underwent 11C-2-ß-carbomethoxy-3-b-(4-fluorophenyl) tropane (11C-CFT) and 2-(4-N-[11C] methylaminophenyl)-6-hydroxybenzothiazole (11C-PiB) PET/MRI were retrospectively included in the study. Each PET LIST mode data were reconstructed with and without the TOF reconstruction algorithm. Standard uptake values (SUVs) of Caudate Nucleus (CN), Putamen (PU), and Whole-brain (WB) were measured. TOF and non-TOF SUVs were assessed by using paired t-test. Standard formulas were applied to measure contrast, signal-to-noise ratio (SNR), and percentage relative average difference of SUVs (%RAD-SUVs). Total 75 patients were included with the median age (years) and body mass index (BMI-kg/m2) of 60.2 ± 10.9 years and 23.9 ± 3.7 kg/m2 in 11C-CFT (n = 41) and 62.2 ± 6.8 years and 24.7 ± 2.9 kg/m2 in 11C-PiB (n = 34), respectively. Higher average SUVs and positive %RAD-SUVs were observed in CN and PU in TOF compared with non-TOF reconstructions for the two 11C-labeled radiotracers. Differences of SUVmean were significant (p < 0.05) in CN and PU for both 11C-labeled radiotracers. SUVmax was enhanced significantly in CN and PU for 11C-CFT and CN for 11C-PiB, but not in PU. Significant contrast enhancement was observed in PU for both 11C-labeled radiotracers, whereas SNR gain was significant in PU, only for 11C-PiB in TOF reconstruction. Time-of-flight leads to a better signal vs. noise trade-off than non-TOF in 11C-labeled tracers between CN and PU, improving the SUVs, contrast, and SNR, which were valuable for reducing injected radiation dose. Improved timing resolution aided the rapid decay rate of short-lived 11C-labeled tracers, and it shortened the scan time, increasing the patient comfort, and reducing the motion artifact among patients with AD/PD. However, one should adopt the combined TOF algorithm with caution for the quantitative analysis because it has different effects on the SUVmax, contrast, and SNR of different brain regions.
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