A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia.
A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia.
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DOI：
10.1016/j.oraloncology.2013.05.011
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发表时间：
2013-09
期刊：
影响因子：
4.8
通讯作者：
Szabo, Eva
中科院分区：
文献类型：
--
作者：
Wong, Stuart J.;Campbell, Bruce;Massey, Becky;Lynch, Denis P.;Cohen, Ezra E. W.;Blair, Elizabeth;Selle, Rebecca;Shklovskaya, Julia;Jovanovic, Borko D.;Skripkauskas, Silvia;Dew, Alexander;Kulesza, Peter;Parimi, Vamsi;Bergan, Raymond C.;Szabo, Eva
氨基乙酰丙酸光动力疗法（ALA PDT）治疗口腔白斑在消退口腔白斑方面显示出良好的效果。虽然ALA已被广泛研究，是一种理想的光敏剂，但治疗口腔白斑的最佳光剂量尚未确定。我们进行了一项I期研究，以确定ALA治疗白斑患者PDT的MTD和DLT。组织学证实的口腔白斑患者接受了ALA PDT的单次治疗，队列中的光剂量递增（585 nm）。评估了临床、组织学和生物学标志物。分析了11名参与者的报告。在接受高达4 J/cm 2的光剂量ALA的患者中未观察到ALA PDT的显著毒性。1例受试者因ALA发生一过性3级转氨酶升高。一名参与者在治疗后3个月出现部分临床反应。生物粘膜风险标志物显示无显著相关性。无法在完成研究的可行时间范围内确定MTD。ALA PDT可以安全地以高达4 J/cm 2的光剂量施用，并表现出活性。需要更大规模的研究来充分阐明ALA-PDT的MTD和疗效。
Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been determined. We conducted a phase I study to determine MTD and DLT of PDT in patients treated with ALA for leukoplakia. Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585 nm). Clinical, histologic, and biologic markers were assessed. Analysis of eleven participants is reported. No significant toxicity from ALA PDT was observed in patients who received ALA with a light dose of up to 4 J/cm2. One participant experienced transient grade 3 transaminase elevation due to ALA. One participant had a partial clinical response 3 months after treatment. Biologic mucosal risk markers showed no significant associations. Determination of MTD could not be accomplished within a feasible timeframe for completion of the study. ALA PDT could be safely administered with a light dose up to 4 J/cm2 and demonstrated activity. Larger studies are needed to fully elucidate the MTD and efficacy of ALA-PDT.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
3.3
作者：
Lin, Hung-Pin;Chen, Hsin-Ming;Chiang, Chun-Pin
通讯作者：
Chiang, Chun-Pin
DOI：
10.1007/s00464-003-9062-4
发表时间：
2004-03-01
影响因子：
3.1
作者：
Kelty, CJ;Ackroyd, R;Reed, MWR
通讯作者：
Reed, MWR
影响因子：
3.3
作者：
Ackroyd, R;Brown, N;Reed, M
通讯作者：
Reed, M
影响因子：
29.4
作者：
Gossner, L;Stolte, M;Ell, C
通讯作者：
Ell, C