Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-Analysis.
Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-Analysis.
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中国不同地区幽门螺杆菌原发性耐药的系统评价和荟萃分析
DOI：
10.3390/pathogens11070786
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发表时间：
2022-07-12
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影响因子：
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中科院分区：
文献类型：
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目的：了解抗生素耐药性的流行情况可以为选择治疗方案提供可靠的信息。本荟萃分析的目的是观察中国不同地区和不同时期幽门螺杆菌（h.p ylori）的主要抗生素耐药性。方法：检索PubMed、EMBASE、中国生物医学数据库和中国国家知识基础设施数据库，检索时间为成立至2022年2月20日。包括不同时间点幽门螺杆菌原发性耐药流行率的数据。建立随机效应模型，计算综合抗生素耐药性。结果：共检索到2150篇文献，其中70篇符合纳入标准。2016-2020年对克拉霉素、甲硝唑、左氧氟沙星阿莫西林、四环素和呋喃唑酮的耐药率分别为34% （95%CI: 30-39%）、78% （95%CI: 73-84%）、35% （95%CI: 30-40%）、3% （95%CI: 1-5%）、2% （95%CI: 1-4%）和1% （95%CI: 0-4%）。克拉霉素耐药率在中国北部（37%,95% CI: 32-41%）和西部（35%,95% CI: 17-54%）高于南方（24%,95% CI: 17-32%）和东部（24%,95% CI: 20-28%）。结论：幽门螺杆菌对克拉霉素、甲硝唑的耐药程度较高，且随时间推移呈上升趋势，而对左氧氟沙星、阿莫西林、四环素、呋喃唑酮的耐药程度保持稳定。
Aim: Understanding the prevalence of antibiotic resistance can provide reliable information for selecting treatment options. The goal of this meta-analysis was to observe the primary antibiotic resistance of Helicobacter pylori (H. pylori) in different regions and time periods of China. Method: We searched PubMed, EMBASE, Chinese Biomedical databases and the China National Knowledge Infrastructure from inception to 20 February 2022. Data on the prevalence of H. pylori primary resistance at various time points were included. A random-effect model was established to calculate the pooled antibiotic resistance. Results: In total, 2150 articles were searched, with 70 meeting the inclusion criteria. The resistance to clarithromycin, metronidazole, levofloxacin amoxicillin, tetracycline and furazolidone in 2016–2020 were 34% (95% CI: 30–39%), 78% (95% CI: 73–84%), 35% (95% CI: 30–40%), 3% (95% CI: 1–5%), 2% (95%CI: 1–4%) and 1% (95% CI: 0–4%), respectively. Clarithromycin showed regional difference, as the resistance was higher in northern (37%, 95% CI: 32–41%) and western China (35%, 95% CI: 17–54%) than that in southern (24%, 95% CI: 17–32%) and eastern China (24%, 95% CI: 20–28%). Conclusion: The resistance of H. pylori to clarithromycin and metronidazole was high and increased over time, whereas resistance to levofloxacin, amoxicillin, tetracycline and furazolidone remained stable.
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影响因子：
3.9
作者：
Gao, Chun;Du, Shi-Yu;Chen, Huang
通讯作者：
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作者：
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通讯作者：
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3.1
作者：
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作者：
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影响因子：
24.5
作者：
Dore, Maria Pina;Lu, Hong;Graham, David Y.
通讯作者：
Graham, David Y.