Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial.
Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial.
复制标题
咖啡因和脱咖啡因咖啡对2型糖尿病生物危险因素的影响：一项随机对照试验。
DOI：
10.1186/1475-2891-10-93
复制
发表时间：
2011-09-13
影响因子：
5.4
通讯作者：
van Dam RM
中科院分区：
文献类型：
--
作者：
Wedick NM;Brennan AM;Sun Q;Hu FB;Mantzoros CS;van Dam RM
在前瞻性队列研究中，咖啡消费与2型糖尿病的风险降低有关，但其潜在机制仍不清楚。这项研究的目的是评估普通咖啡和无咖啡因咖啡对2型糖尿病生物危险因素的影响。在45名健康超重的志愿者中进行了随机平行臂干预，这些志愿者是不吸烟者和经常喝咖啡的人。参与者被分配每天消费5杯（每杯177 mL）速溶咖啡、无咖啡因咖啡或不喝咖啡（即，水）8周。平均年龄为40岁，体重指数为29.5 kg/m2。与不喝咖啡相比，喝含咖啡因的咖啡可增加脂联素（较基线变化的差异为1.4 μg/mL; 95% CI：0.2，2.7）和白细胞介素-6（差异：60%; 95% CI：8，138）的浓度，喝脱咖啡因的咖啡可降低胎球蛋白A浓度（差异：-20%; 95% CI：-35，-1）。对于葡萄糖耐量、胰岛素敏感性和胰岛素分泌的测量，未发现治疗组之间存在显著差异。虽然在饮用咖啡8周后没有观察到胰岛素和/或胰岛素敏感性的变化，但脂联素和胎球蛋白A浓度的变化表明脂肪细胞和肝功能的改善可能有助于长期饮用咖啡的有益代谢作用。clinicaltrials.gov NCT00305097
Coffee consumption has been associated with a lower risk of type 2 diabetes in prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes. Randomized parallel-arm intervention conducted in 45 healthy overweight volunteers who were nonsmokers and regular coffee consumers. Participants were assigned to consumption of 5 cups (177 mL each) per day of instant caffeinated coffee, decaffeinated coffee, or no coffee (i.e., water) for 8 weeks. Average age was 40 years and body mass index was 29.5 kg/m2. Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin (difference in change from baseline 1.4 μg/mL; 95% CI: 0.2, 2.7) and interleukin-6 (difference: 60%; 95% CI: 8, 138) concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations (difference: -20%; 95% CI: -35, -1). For measures of glucose tolerance, insulin sensitivity, and insulin secretion, no significant differences were found between treatment groups. Although no changes in glycemia and/or insulin sensitivity were observed after 8 weeks of coffee consumption, improvements in adipocyte and liver function as indicated by changes in adiponectin and fetuin-A concentrations may contribute to beneficial metabolic effects of long-term coffee consumption. clinicaltrials.gov NCT00305097
登录
查看更多内容
影响因子：
7.1
作者：
Zampelas, A;Panagiotakos, DB;Stefanadis, C
通讯作者：
Stefanadis, C
脱咖啡因咖啡和主要咖啡成分绿原酸和葫芦巴碱对葡萄糖耐量的急性影响。
影响因子：
16.2
作者：
van Dijk AE;Olthof MR;Meeuse JC;Seebus E;Heine RJ;van Dam RM
通讯作者：
van Dam RM
影响因子：
4.2
作者：
TRUGO, LC;MACRAE, R
通讯作者：
MACRAE, R
影响因子：
6.8
作者：
Kotani, Kazuhiko;Tsuzaki, Kokoro;Sakane, Naoki
通讯作者：
Sakane, Naoki
影响因子：
3.4
作者：
Tunnicliffe, Jasmine M.;Shearer, Jane
通讯作者：
Shearer, Jane