Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.
Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.
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DOI：
10.1016/j.clnu.2021.02.006
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Hellmann J
中科院分区：
文献类型：
--
作者：
Farley G;Riggs DW;Bhatnagar A;Hellmann J
运动可以提高生活质量，降低全因死亡率，可能是通过预防心血管疾病。虽然运动的有益效果与慢性炎症的减少有关，但个体反应各不相同，导致心血管健康抗炎作用的因素在很大程度上仍不确定。我们试图研究脂肪酸在炎症和心血管健康之间的反比关系中的作用。在这项横断面研究中，使用来自NHANES的435名参与者的数据和以CRP为结果的线性回归模型，我们观察到VO 2 max和omega-3多不饱和脂肪酸（PUFA）之间存在显著的负相互作用，但不饱和，单不饱和或omega-6 PUFA。当按omega-3 PUFA三分位数分层时，中三分位数而非低三分位数的参与者显示VO 2 max与CRP之间的负相关性增强，每10 mL/kg/min VO 2 max的差异为−32.0%（95% CI：−44.95，−15.9%）。探索性因素分析确定了五个独特的膳食脂肪酸（FA）配置文件。主要由omega-3 PUFA组成的FA谱与VO 2 max和CRP的负相关性最强，每10 mL/kg/min的VO 2 max，CRP差异为−28.2%（95% CI：−43.4，−8.9）。我们还发现，α-亚麻酸（ALA）和二十二碳六烯酸（DHA）增强了VO 2 max和CRP之间的负相关性，这表明VO 2 max能力的抗炎反应与ALA和DHA水平相关。男性，白人和BMI较低的个体对omega-3 PUFA的影响更敏感，而高SFA水平则会减弱这种益处。这项研究表明，omega-3多不饱和脂肪酸是VO 2 max和CRP的效应调节剂，心血管健康的抗炎益处与omega-3多不饱和脂肪酸有关。
Exercise increases quality of life and lowers all-cause mortality, likely by preventing cardiovascular disease. Although the beneficial effects of exercise are linked with reductions in chronic inflammation, individual responses vary and factors that contribute to the anti-inflammatory effects of cardiovascular fitness remain largely undefined. We sought to investigate the role of fatty acids in the inverse relationship between inflammation and cardiovascular fitness. In this cross-sectional study using data from 435 participants in NHANES and linear regression models with CRP as the outcome, we observed significant negative interactions between VO2max and omega-3 polyunsaturated fatty acids (PUFAs) but not saturated, monounsaturated, or omega-6 PUFAs. When stratified by omega-3 PUFA tertiles, participants in the medium tertile, but not low tertile, show an enhanced negative association between VO2max and CRP, with a −32.0% difference (95% CI: −44.95, −15.9%) per 10 mL/kg/min of VO2max. Exploratory factor analysis identified five unique dietary fatty acid (FA) profiles. The FA profile consisting predominantly of omega-3 PUFA had the strongest negative association for VO2max and CRP, with a −28.2% difference in CRP (95% CI: −43.4, −8.9) per 10 mL/kg/min of VO2 max. We also found that alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) enhanced the negative association between VO2max and CRP, suggesting that the anti-inflammatory response to VO2max capacity is associated with ALA and DHA levels. Males, whites, and individuals with lower BMI were more sensitive to the effects of omega-3 PUFAs, while having high SFA levels attenuated the benefit. This study suggests that omega-3 PUFAs are effect modifiers for VO2max and CRP and that the anti-inflammatory benefits of cardiovascular fitness are associated with omega-3 PUFAs.
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影响因子：
16.6
作者：
Fredman, Gabrielle;Hellmann, Jason;Proto, Jonathan D.;Kuriakose, George;Colas, Romain A.;Dorweiler, Bernhard;Connolly, E. Sander;Solomon, Robert;Jones, David M.;Heyer, Eric J.;Spite, Matthew;Tabas, Ira
通讯作者：
Tabas, Ira
DOI：
10.1249/mss.0b013e3181b117ca
发表时间：
2010-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Donges, Cheyne E.;Duffield, Rob;Drinkwater, Eric J.
通讯作者：
Drinkwater, Eric J.
影响因子：
39.3
作者：
Lakka, TA;Lakka, HM;Bouchard, C
通讯作者：
Bouchard, C
影响因子：
3.8
作者：
Lagerstedt, SA;Hinrichs, DR;McConnell, JP
通讯作者：
McConnell, JP
影响因子：
4.4
作者：
Claria, Joan;Dalli, Jesmond;Serhan, Charles N.
通讯作者：
Serhan, Charles N.