Body composition and risk factors for cardiovascular disease in global multi-ethnic populations.
Body composition and risk factors for cardiovascular disease in global multi-ethnic populations.
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DOI：
10.1038/s41366-023-01339-9
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发表时间：
2023-09
影响因子：
4.9
通讯作者：
Jamal, Rahman
中科院分区：
文献类型：
--
作者：
Carter, Jennifer L.;Abdullah, Noraidatulakma;Bragg, Fiona;Murad, Nor Azian Abdul;Taylor, Hannah;Fong, Chin Siok;Lacey, Benjamin;Sherliker, Paul;Karpe, Fredrik;Mustafa, Norlaila;Lewington, Sarah;Jamal, Rahman
没有大规模的研究比较多种族人群中身体成分和心血管危险因素之间的关联。基于人口的调查包括来自马来西亚队列的30，721名马来人、10，865名印度人和25，296名华人成年人，以及来自英国生物库的413，737名白色成年人。性别特异性线性回归模型估计了人体测量和身体组成（体重指数[BMI]，腰围[WC]，脂肪量，apapperiallean质量）与收缩压（SBP），低密度脂蛋白胆固醇（LDL-C），甘油三酯和HbA 1c的相关性。与马来人和印度人相比，中国成年人的BMI和脂肪量较低，而白色参与者更高，瘦体重更明显。对于BMI和脂肪量，与SBP和HbA 1c的正相关性在华人和马来人中最强，而在白色参与者中较弱。在印度种族中，与甘油三酯的相关性明显较弱（例如，男性为0.09 [0.02] mmol/L/5 kg/m2 BMI，中国人为0.38 [0.02] mmol/L）。对于非典型的瘦体重，男性之间的相关性较弱;但在马来人和印度女性中，与SBP、甘油三酯和HbA 1c的正相关性较强，与LDL-C的负相关性较强。WC和危险因素之间的关联在中国人中最强，在印度人中最弱，尽管这种模式在HbA 1c中被逆转。不同种族人群的肥胖、身体成分和心血管危险因素有不同的模式。我们需要更好地了解身体成分与心血管风险相关的机制，以减轻肥胖相关疾病日益增加的全球负担。
No large-scale studies have compared associations between body composition and cardiovascular risk factors across multi-ethnic populations. Population-based surveys included 30,721 Malay, 10,865 Indian and 25,296 Chinese adults from The Malaysian Cohort, and 413,737 White adults from UK Biobank. Sex-specific linear regression models estimated associations of anthropometry and body composition (body mass index [BMI], waist circumference [WC], fat mass, appendicular lean mass) with systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), triglycerides and HbA1c. Compared to Malay and Indian participants, Chinese adults had lower BMI and fat mass while White participants were taller with more appendicular lean mass. For BMI and fat mass, positive associations with SBP and HbA1c were strongest among the Chinese and Malay and weaker in White participants. Associations with triglycerides were considerably weaker in those of Indian ethnicity (eg 0.09 [0.02] mmol/L per 5 kg/m2 BMI in men, vs 0.38 [0.02] in Chinese). For appendicular lean mass, there were weak associations among men; but stronger positive associations with SBP, triglycerides, and HbA1c, and inverse associations with LDL-C, among Malay and Indian women. Associations between WC and risk factors were generally strongest in Chinese and weakest in Indian ethnicities, although this pattern was reversed for HbA1c. There were distinct patterns of adiposity and body composition and cardiovascular risk factors across ethnic groups. We need to better understand the mechanisms relating body composition with cardiovascular risk to attenuate the increasing global burden of obesity-related disease.
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影响因子：
6.9
作者：
Eastwood, Sophie V.;Tillin, Therese;Dehbi, Hakim-Moulay;Wright, Andrew;Forouhi, Nita G.;Godsland, Ian;Whincup, Peter;Sattar, Naveed;Hughes, Alun D.;Chaturvedi, Nishi
通讯作者：
Chaturvedi, Nishi
影响因子：
8.2
作者：
Narayan KMV;Kanaya AM
通讯作者：
Kanaya AM
骨骼肌质量和脂肪质量与心血管疾病和全因死亡率的关联：英国生物银行参与者的前瞻性队列研究。
影响因子：
5.4
作者：
Knowles R;Carter J;Jebb SA;Bennett D;Lewington S;Piernas C
通讯作者：
Piernas C
DOI：
10.1016/s2214-109x(18)30267-5
发表时间：
2018-07
期刊：
The Lancet. Global health
影响因子：
--
作者：
Gajalakshmi V;Lacey B;Kanimozhi V;Sherliker P;Peto R;Lewington S
通讯作者：
Lewington S
影响因子：
4.5
作者：
Moy FM;Bulgiba A
通讯作者：
Bulgiba A