Lung carcinogenesis by tobacco smoke.
Lung carcinogenesis by tobacco smoke.
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DOI：
10.1002/ijc.27816
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发表时间：
2012-12-15
影响因子：
6.4
通讯作者：
Hecht, Stephen S.
中科院分区：
文献类型：
--
作者：
Hecht, Stephen S.
香烟烟雾是化学物质的复杂混合物，包括多种基因毒性致癌物。致癌物质代谢激活DNA加合物的经典机制，导致关键生长控制基因的错误编码和突变，适用于这种混合物，但由于暴露的复杂性，有些方面难以确定。本文讨论了该机制的某些特点，包括尼古丁及其受体的作用；香烟烟雾中的肺致癌物、共致癌物及相关物质；吸烟者肺部结构特征的DNA加合物；吸烟者肺部DNA加合物形成的突变后果；以及与肺癌相关的尼古丁和致癌物摄取的生物标志物。虽然仍然存在可能永远无法完全解决的不确定性，但吸烟导致肺癌的一般机制已得到充分了解，并为预防肺癌提供了相关见解。肺癌是世界上头号癌症杀手，每年造成137万人死亡。
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts, leading to miscoding and mutations in critical growth control genes, applies to this mixture but some aspects are difficult to establish because of the complexity of the exposure. This paper discusses certain features of this mechanism including the role of nicotine and its receptors; lung carcinogens, co-carcinogens and related substances in cigarette smoke; structurally characterized DNA adducts in the lungs of smokers; the mutational consequences of DNA adduct formation in smokers’ lungs; and biomarkers of nicotine and carcinogen uptake as related to lung cancer. While there are still uncertainties which may never be fully resolved, the general mechanisms by which cigarette smoking causes lung cancer are well understood and provide insights relevant to prevention of lung cancer, the number one cancer killer in the world, causing 1.37 million deaths per year.
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DOI：
10.1158/1940-6207.capr-08-0082
发表时间：
2008-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Etzel CJ;Kachroo S;Liu M;D'Amelio A;Dong Q;Cote ML;Wenzlaff AS;Hong WK;Greisinger AJ;Schwartz AG;Spitz MR
通讯作者：
Spitz MR
影响因子：
2.7
作者：
Anna, Livia;Kovacs, Katalin;Nair, Jagadeesan
通讯作者：
Nair, Jagadeesan
影响因子：
10.3
作者：
Cronin, Kathleen A.;Gail, Mitchell H.;Albanes, Demetrius
通讯作者：
Albanes, Demetrius
影响因子：
10.3
作者：
DONTENWILL, W;CHEVALIER, HJ;SCHNEIDER, B
通讯作者：
SCHNEIDER, B
人类癌基因组中体细胞突变的模式。
影响因子：
64.8
作者：
Greenman, Christopher;Stephens, Philip;Smith, Raffaella;Dalgliesh, Gillian L.;Hunter, Christopher;Bignell, Graham;Davies, Helen;Teague, Jon;Butler, Adam;Edkins, Sarah;O'Meara, Sarah;Vastrik, Imre;Schmidt, Esther E.;Avis, Tim;Barthorpe, Syd;Bhamra, Gurpreet;Buck, Gemma;Choudhury, Bhudipa;Clements, Jody;Cole, Jennifer;Dicks, Ed;Forbes, Simon;Gray, Kris;Halliday, Kelly;Harrison, Rachel;Hills, Katy;Hinton, Jon;Jenkinson, Andy;Jones, David;Menzies, Andy;Mironenko, Tatiana;Perry, Janet;Raine, Keiran;Richardson, Dave;Shepherd, Rebecca;Small, Alexandra;Tofts, Calli;Varian, Jennifer;Webb, Tony;West, Sofie;Widaa, Sara;Yates, Andy;Cahill, Daniel P.;Louis, David N.;Goldstraw, Peter;Nicholson, Andrew G.;Brasseur, Francis;Looijenga, Leendert;Weber, Barbara L.;Chiew, Yoke-Eng;deFazio, Anna;Greaves, Mel F.;Green, Anthony R.;Campbell, Peter;Birney, Ewan;Easton, Douglas F.;Chenevix-Trench, Georgia;Tan, Min-Han;Khoo, Sok Kean;Teh, Bin Tean;Yuen, Siu Tsan;Leung, Suet Yi;Wooster, Richard;Futreal, P. Andrew;Stratton, Michael R.
通讯作者：
Stratton, Michael R.