Telomere length in myelodysplastic syndromes.
Telomere length in myelodysplastic syndromes.
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DOI：
10.3109/10428194.2011.568648
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发表时间：
2011-08
影响因子：
2.6
通讯作者：
List AF
中科院分区：
文献类型：
--
作者：
Rollison DE;Epling-Burnette PK;Park JY;Lee JH;Park H;Jonathan K;Cole AL;Painter JS;Guerrier M;Meléndez-Santiago J;Fulp W;Komrokji R;Lancet J;List AF
端粒长度（TL）与骨髓增生异常综合征（MDS）易感性之间的关系尚不清楚。我们比较了未经治疗且无既往癌症史的经组织学证实的MDS病例（n=65）与年龄匹配的对照组（n=63）的外周血白细胞（PBL）TL。通过定量PCR测量PBL和唾液中的相对TL，并通过Flow-FISH测量CD 15+和CD 19+细胞中的相对TL。PCR检测端粒酶逆转录酶基因（hTERT）突变。校正年龄和性别后，MDS病例与对照组相比，PBL（p=0.02）、CD 15+（p=0.01）、CD 19+（p=0.25）和唾液（p=0.13）的相对TL降低，尽管只有PBL和CD 15+结果具有统计学显著性。在MDS病例中，CD 15+和CD 19+细胞TL呈正相关（p=0.03）。PBL TL在职业暴露于油漆和农药的人群中减少，但与hTERT基因型无关。未来的研究需要进一步调查宪法端粒磨损作为一个可能的诱发因素MDS。
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically-confirmed MDS (n=65) who were treatment-naive with no prior cancer history to age-matched controls (n=63). Relative TL was measured in PBL and saliva by quantitative PCR and in CD15+ and CD19+ cells by Flow-FISH. Human telomerase reverse transcriptase gene (hTERT) mutations were assessed by PCR. After adjustment for age and sex, relative TLs were reduced in PBL (p=0.02), CD15+ (p=0.01), CD19+ (p=0.25) and saliva (p=0.13) in MDS cases versus controls, although only PBL and CD15+ results were statistically significant. Among MDS cases, CD15+ and CD19+ cell TLs positively correlated (p=0.03). PBL TL was reduced among those occupationally exposed to paints and pesticides, but was not associated with hTERT genotype. Future studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS.
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影响因子：
2.2
作者：
Kapoor, Veena;Hakim, Fran T.;Telford, William G.
通讯作者：
Telford, William G.
影响因子：
6.5
作者：
Rigolin, GM;Cuneo, A;Castoldi, G
通讯作者：
Castoldi, G
DOI：
10.1196/annals.1297.044
发表时间：
2004-01-01
期刊：
STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE
影响因子：
--
作者：
Baird, DM;Kipling, D
通讯作者：
Kipling, D
影响因子：
2.3
作者：
Mirabello, Lisa;Garcia-Closas, Montserrat;Cawthon, Richard;Lissowska, Jolanta;Brinton, Louise A.;Peplonska, Beata;Sherman, Mark E.;Savage, Sharon A.
通讯作者：
Savage, Sharon A.
影响因子：
3.8
作者：
McGrath, Monica;Wong, Jason Y. Y.;De Vivo, Immaculata
通讯作者：
De Vivo, Immaculata