Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.
Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.
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DOI：
10.3390/jcm4030425
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发表时间：
2015-03
影响因子：
3.9
通讯作者：
Klein BE
中科院分区：
文献类型：
--
作者：
Klein R;Myers CE;Lee KE;Gangnon RE;Sivakumaran TA;Iyengar SK;Klein BE
我们检验了大面积的小硬玻璃疣（直径<63 µm）和中等玻璃疣（直径63-124 µm）与年龄相关性黄斑变性（AMD）发病率相关的假设。包括3344名老年人的眼睛，在20年的时间内至少连续两次间隔5年的访问。使用6级严重程度量表，包括无玻璃疣、仅小的硬玻璃疣和中等玻璃疣的4个增加面积等级（从最小（<2596 µ m ²）到大（>9086 µm²））。在间隔开始时，无、轻微、小和中度区域仅有小玻璃疣的眼睛中AMD的5年发病率为3%，而大区域仅有小玻璃疣和中度玻璃疣的眼睛中AMD的5年发病率分别为5%和25%。与有中等面积小玻璃疣的眼睛相比，只有大面积小玻璃疣的眼睛发生AMD的比值比（OR）为1.8（p < 0.001）。与只有小玻璃疣的大面积眼睛相比，中度玻璃疣的眼睛发展为AMD的OR为5.5（p < 0.001）。我们的研究结果与我们的假设一致，即大面积的小玻璃疣与AMD的发病率有关。
We tested the hypothesis that large areas of small hard drusen (diameter <63 µm) and intermediate drusen (diameter 63–124 µm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least two consecutive visits spaced five years apart over a 20-year period were included. A 6-level severity scale, including no drusen, four levels of increasing area (from minimal (<2596 µm²) to large (>9086 µm²)) of only small hard drusen, and intermediate drusen, was used. The five-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (p < 0.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (p < 0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.
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影响因子：
13.7
作者：
Mitchell, P;Wang, JJ;Smith, W
通讯作者：
Smith, W
影响因子：
13.7
作者：
Klein, R;Klein, BEK;Lee, KE
通讯作者：
Lee, KE
DOI：
10.1007/s00417-014-2690-7
发表时间：
2014-08-01
影响因子：
2.7
作者：
Dietzel, Martha;Pauleikhoff, Daniel;Hense, Hans-Werner
通讯作者：
Hense, Hans-Werner
CFH和ARM2中的风险等位基因以及与年龄相关的黄斑变性的长期自然历史：Beaver Dam Eye研究。
影响因子：
8.1
作者：
Klein, Ronald;Klein, Ronald;Myers, Chelsea E.;Meuer, Stacy M.;Gangnon, Ronald E.;Sivakumaran, Theru A.;Iyengar, Sudha K.;Lee, Kristine E.;Klein, Barbara E. K.
通讯作者：
Klein, Barbara E. K.
影响因子：
1.8
作者：
Klein, Ronald;Meuer, Stacy M.;Klein, Barbara E. K.
通讯作者：
Klein, Barbara E. K.