Polydopamine nanoparticles as dual-task platform for osteoarthritis therapy: A scavenger for reactive oxygen species and regulator for cellular powerhouses
Polydopamine nanoparticles as dual-task platform for osteoarthritis therapy: A scavenger for reactive oxygen species and regulator for cellular powerhouses
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聚多巴胺纳米颗粒作为骨关节炎治疗的双任务平台：活性氧的清除剂和细胞动力室的调节剂
DOI：
10.1016/j.cej.2021.129284
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发表时间：
2021-08
影响因子：
15.1
通讯作者：
Shen Steve G.
中科院分区：
文献类型：
--
作者：
Wang Xiangyu;Zhao Hanjiang;Liu Zhenchuan;Wang Yitong;Lin Dan;Chen Long;Dai Jiewen;Lin Kaili;Shen Steve G.
由于骨关节炎（OA）病因不明，治疗效果不理想，迫切需要新的有效和微创的治疗方法。由过量活性氧（ROS）积累引起的氧化应激历来被认为是OA的潜在触发因素。聚多巴胺（PDA）是一种由多巴胺自聚合而成的新型多功能生物高分子材料，具有良好的生物相容性和清除活性氧的能力，在生物医学领域有着广泛的应用前景。本文介绍了一种基于PDA纳米颗粒（NP）的抗氧化/抗炎双重任务纳米平台，用于治疗颞下颌关节骨关节炎（TMJ-OA）。除了作为还原剂直接与ROS反应外，PDA NP还调节线粒体中的ROS生成，线粒体被认为是细胞动力室。具体地，线粒体氧化磷酸化（OXPHOS）的效率在PDA NP的存在下显著增加，表明PDA NP可以增加线粒体呼吸的效率，因此减少ROS产生。这种有趣的双重抗氧化机制可能是PDA纳米颗粒具有显著抗氧化能力的原因。此外，PDA纳米粒的抗炎能力在体外和体内均被揭示。这项工作不仅为OA治疗开辟了新的途径，而且通过调节细胞能量代谢为具有多种生物医学应用的生物材料的设计提供了有价值的见解。
Because of the obscure etiology of osteoarthritis (OA) and unsatisfactory treatment outcomes, new effective and minimally invasive therapies are urgently needed. Oxidative stress elicited by excessive reactive oxygen species (ROS) accumulation has historically been considered a potential trigger of OA. Polydopamine (PDA), an emerging versatile biopolymer produced by self-polymerization of dopamine, has attracted considerable attention in biomedical applications by virtue of its excellent biocompatibility and intriguing ROS-scavenging capacity. Herein, an antioxidative/anti-inflammatory dual-task nanoplatform based on PDA nanoparticles (NPs) is introduced for the treatment of temporomandibular joint osteoarthritis (TMJ-OA). In addition to directly reacting with ROS as a reducing agent, PDA NPs also regulate ROS generation in mitochondria which are considered cellular powerhouses. Specifically, the efficiency of mitochondrial oxidative phosphorylation (OXPHOS) is significantly increased in the presence of PDA NPs, indicating that PDA NPs may increase the efficiency of mitochondrial respiration, hence reducing ROS production. This intriguing dual-antioxidative mechanism may account for the remarkable antioxidative capacity of PDA NPs. Moreover, the anti-inflammatory capacity of PDA NPs is revealed bothin vitroandin vivo. This work not only opens a new avenue for OA treatment but also provides valuable insights into the design of biomaterials with multiple biomedical applications via regulation of cellular energy metabolism.
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影响因子：
3.3
作者：
Gollmer, Anita;Arnbjerg, Jacob;Ogilby, Peter R.
通讯作者：
Ogilby, Peter R.
DOI：
10.1007/978-3-030-39982-5_7
发表时间：
2020
期刊：
Pain Management for Clinicians
影响因子：
--
作者：
Nilofar Syed;Una E. Makris
通讯作者：
Nilofar Syed;Una E. Makris
影响因子：
5.6
作者：
Hu Q;Ecker M
通讯作者：
Ecker M
影响因子：
64.5
作者：
TOLEDANO, MB;KULLIK, I;STORZ, G
通讯作者：
STORZ, G
DOI：
10.1016/s0889-5406(05)81195-3
发表时间：
1992
期刊：
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
影响因子：
--
作者：
J. Okun
通讯作者：
J. Okun