Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.
Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.
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DOI：
10.1002/eji.201040559
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发表时间：
2010-07
影响因子：
5.4
通讯作者：
Tsai, Mindy
中科院分区：
文献类型：
--
作者：
Galli, Stephen J.;Tsai, Mindy
肥大细胞广泛分布于组织中，特别是暴露于环境的表面附近。肥大细胞可以被IgE和特异性抗原以及许多其他刺激物激活以分泌多种介质和细胞因子，包括在先天免疫应答期间来自病原体或宿主的产物。虽然肥大细胞在IgE相关过敏性疾病中的作用最为人所知，但肥大细胞也可加剧自身免疫模型，增强某些皮肤接触性超敏反应（CHS）反应的致敏和/或效应阶段，并在某些严重细菌感染期间增加炎症和死亡率。然而，在其他环境中，肥大细胞可以限制炎症和组织损伤：肥大细胞在某些细菌或寄生虫感染模型中促进宿主抵抗力，在对环境抗原的某些获得性免疫反应期间限制病理，包括严重接触性超敏反应的例子，并且具有佐剂样特性，可以增强针对病原体的保护性免疫的发展。这些和其他研究结果表明，肥大细胞在先天性和获得性免疫的界面上占据了一个关键的利基，在那里，取决于仍有待完全理解的情况，肥大细胞可能会扰乱或帮助恢复稳态（或两者兼而有之），其后果可能是促进健康或导致疾病。
Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific antigen and many other stimuli, including products derived from either pathogens or the host during innate immune responses. While mast cells are best known for their role in IgE-associated allergic disorders, mast cells can also exacerbate models of autoimmunity, enhance the sensitization and/or effector phases of certain cutaneous contact hypersensitivity (CHS) responses, and increase inflammation and mortality during some severe bacterial infections. In other settings, however, mast cells can limit inflammation and tissue injury: mast cells promote host resistance in certain models of bacterial or parasite infection, limit pathology during some acquired immune responses to environmental antigens, including examples of severe contact hypersensitivity, and have adjuvant-like properties that can enhance the development of protective immunity against pathogens. These and other findings suggest that mast cells occupy a critical niche at the interface of innate and acquired immunity, where, depending on circumstances that remain to be fully understood, mast cells may function to perturb or help to restore homeostasis (or both), with consequences that can either promote health or contribute to disease.
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影响因子：
64.8
作者：
Malaviya, R;Ikeda, T;Abraham, SN
通讯作者：
Abraham, SN
影响因子：
4.4
作者：
Furuta, Takahisa;Kikuchi, Takane;Watanabe, Naohiro
通讯作者：
Watanabe, Naohiro
DOI：
10.1084/jem.20091903
发表时间：
2009-09-28
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Wynn TA
影响因子：
30.5
作者：
Grimbaldeston, Michele A.;Nakae, Susumu;Galli, Stephen J.
通讯作者：
Galli, Stephen J.
影响因子：
100.3
作者：
Galli, Stephen J.;Grimbaldeston, Michele;Tsai, Mindy
通讯作者：
Tsai, Mindy