Explorations of object and location memory using fMRI.

Explorations of object and location memory using fMRI.
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DOI:
10.3389/fnbeh.2013.00105
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发表时间:
2013
影响因子:
3
通讯作者:
Wright AA
Wright AA
中科院分区:
医学3区
文献类型:
--
作者:
Passaro AD;Elmore LC;Ellmore TM;Leising KJ;Papanicolaou AC;Wright AA

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视觉工作记忆(VWM)的特定于内容的子系统已经在许多神经成像研究中被探索,但在实验中发现和程序不一致。本研究使用了功能磁共振成像(FMRI)和变化检测任务,使用了大量试验,并匹配了对象和位置变化(什么与哪里)条件下的刺激显示。此外,在不同条件下对各个任务周期进行了独立研究,以确定每个任务周期对应的差异。重要的是,这种任务控制的组合以前没有在fMRI文献中描述过。综合结果显示,在每个任务期间,额顶顶叶的激活不同。在编码分别对应于双侧顶下小叶(IPL)和舌回激活的信息时,物体和位置条件的分离产生了背侧和腹侧流的分布系统。在双侧额叶结构的信息维持过程中,也表现出不同的活动,对于物体,在右侧的额叶结构中,对于位置,在右侧的IPL和左侧的岛中,信息的保持也不同。总而言之,这些结果反映了跨越几个大脑皮层和任务周期的特定领域的分离。此外,不同的激活分别对应于物体和位置记忆的一般尾部-吻部分离。
Content-specific sub-systems of visual working memory (VWM) have been explored in many neuroimaging studies with inconsistent findings and procedures across experiments. The present study employed functional magnetic resonance imaging (fMRI) and a change detection task using a high number of trials and matched stimulus displays across object and location change (what vs. where) conditions. Furthermore, individual task periods were studied independently across conditions to identify differences corresponding to each task period. Importantly, this combination of task controls has not previously been described in the fMRI literature. Composite results revealed differential frontoparietal activation during each task period. A separation of object and location conditions yielded a distributed system of dorsal and ventral streams during the encoding of information corresponding to bilateral inferior parietal lobule (IPL) and lingual gyrus activation, respectively. Differential activity was also shown during the maintenance of information in middle frontal structures bilaterally for objects and the right IPL and left insula for locations. Together, these results reflect a domain-specific dissociation spanning several cortices and task periods. Furthermore, differential activations suggest a general caudal-rostral separation corresponding to object and location memory, respectively.
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发表时间: 2009-07-01
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