Intravital Imaging of Inflammatory Response in Liver Disease.
Intravital Imaging of Inflammatory Response in Liver Disease.
复制标题
肝病炎症反应的活体成像
DOI：
10.3389/fcell.2022.922041
复制
发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
健康的肝脏需要免疫细胞和非免疫细胞之间严格控制的串扰来维持其功能和稳态。一个良好的免疫系统可以有效地识别和清除有害刺激的自限性，小规模的炎症反应。这种受调节的炎症过程使肝脏能够科普日常微生物暴露和代谢应激，这有利于肝脏自我更新和组织重塑。然而，未能清除有害刺激或免疫应答失调可导致不受控制的肝脏炎症、肝功能障碍和严重的肝脏疾病。许多高度动态的循环免疫细胞和固着驻留免疫和实质细胞以令人难以置信的复杂方式相互作用和交流，以调节健康和患病肝脏中的炎症反应。活体成像是体内单个细胞可视化的强大工具，已广泛用于解剖肝脏复杂结构中各种细胞类型之间的行为和相互作用。在这里，我们总结了一些新的研究结果与使用活体成像，这增强了我们的理解的复杂性，免疫细胞的行为，细胞间的相互作用，和空间组织在生理和病理肝脏炎症反应。
The healthy liver requires a strictly controlled crosstalk between immune and nonimmune cells to maintain its function and homeostasis. A well-conditioned immune system can effectively recognize and clear noxious stimuli by a self-limited, small-scale inflammatory response. This regulated inflammatory process enables the liver to cope with daily microbial exposure and metabolic stress, which is beneficial for hepatic self-renewal and tissue remodeling. However, the failure to clear noxious stimuli or dysregulation of immune response can lead to uncontrolled liver inflammation, liver dysfunction, and severe liver disease. Numerous highly dynamic circulating immune cells and sessile resident immune and parenchymal cells interact and communicate with each other in an incredibly complex way to regulate the inflammatory response in both healthy and diseased liver. Intravital imaging is a powerful tool to visualize individual cells in vivo and has been widely used for dissecting the behavior and interactions between various cell types in the complex architecture of the liver. Here, we summarize some new findings obtained with the use of intravital imaging, which enhances our understanding of the complexity of immune cell behavior, cell–cell interaction, and spatial organization during the physiological and pathological liver inflammatory response.
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影响因子：
56.9
作者：
Bai, Lu;Vienne, Margaux;Tian, Zhigang
通讯作者：
Tian, Zhigang
影响因子：
25.7
作者：
Armbrust, T;Ramadori, G
通讯作者：
Ramadori, G
影响因子：
5.5
作者：
De Filippo K;Rankin SM
通讯作者：
Rankin SM
影响因子：
5.1
作者：
Andrews TS;Atif J;Liu JC;Perciani CT;Ma XZ;Thoeni C;Slyper M;Eraslan G;Segerstolpe A;Manuel J;Chung S;Winter E;Cirlan I;Khuu N;Fischer S;Rozenblatt-Rosen O;Regev A;McGilvray ID;Bader GD;MacParland SA
通讯作者：
MacParland SA
影响因子：
25.7
作者：
Beattie L;Sawtell A;Mann J;Frame TCM;Teal B;de Labastida Rivera F;Brown N;Walwyn-Brown K;Moore JWJ;MacDonald S;Lim EK;Dalton JE;Engwerda CR;MacDonald KP;Kaye PM
通讯作者：
Kaye PM