Aging-related arterial-cardiac interaction in Japanese men
Aging-related arterial-cardiac interaction in Japanese men
复制标题
日本男性与衰老相关的动脉-心脏相互作用
DOI：
10.1007/s00380-008-1145-7
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发表时间：
2009
影响因子：
1.5
通讯作者：
Y. Maruyama
中科院分区：
文献类型：
--
作者：
Y. Maruyama
血管和心脏老化在日本人群中迅速发展。动脉和心脏性能（动脉-心脏相互作用）之间存在密切关系，但年龄和这些参数之间的关系尚未得到很好的研究。本研究的目的是阐明动脉-心脏相互作用与衰老的变化，使用脉搏波速度（PWV）作为动脉粥样硬化的指标。受试者包括595名成年男性（平均年龄58.8 ± 12.2岁），无任何心血管疾病史。在将PWV、心脏结构、心脏功能和血压与年龄相关联后，将受试者分为五个年龄组以比较这些参数的变化。脉搏波传导速度与年龄呈显著正相关（r = 0.461，P <0.01），55岁以上显著增加;左房内径、相对室壁厚度、收缩压、脉压与年龄呈正相关，均随年龄增加而增加。左心室容积与年龄呈负相关，并类似地减少。这些参数与PWV显著相关。主动脉直径（AoD）和EA比值（E/A）与年龄呈负相关，且在PWV增加前变化较早。主动脉内径在45岁以后明显增大，但基本保持平稳，E/A从早期开始呈直线下降。舒张压（DBP）在早期升高，75岁以上降低。动脉粥样硬化与心功能之间存在密切的动脉-心脏相互作用，但AoD、E/A和DBP在早期的变化与动脉粥样硬化无关。
Vascular and cardiac aging is rapidly progressing among the Japanese population. A close relation exists between the artery and cardiac performance (arterial-cardiac interaction), but the relationships between age and these parameters have not been well examined. The aim of this study was to elucidate the changes of arterial-cardiac interaction with aging, using pulse wave velocity (PWV) as an indicator of atherosclerosis. The subjects comprised 595 adult men (mean age, 58.8 ± 12.2 years) without any history of cardiovascular disease. After correlating PWV, cardiac structure, cardiac function, and blood pressure to age, subjects were divided into five age groups to compare changes in these parameters. Pulse wave velocity exhibited a strong positive correlation with age (r= 0.461,P< 0.01) and increased significantly over 55 years old, and left atrial dimension, relative wall thickness, systolic blood pressure, and pulse pressure correlated positively with age and increased similarly. Left ventricular volume correlated negatively with age and decreased similarly. These parameters significantly correlated with PWV. Aortic diameter (AoD) positively and EA ratio (E/A) negatively exhibited a correlation with age and revealed earlier change before PWV increase. Aortic diameter increased significantly over 45 years old and stayed flat, but E/A decreased linearly from the early period. Diastolic blood pressure (DBP) increased in the early period and decreased over 75 years of age. Agerelated atherosclerotic close arterial-cardiac interaction exists between the vessels and cardiac performance, but AoD, E/A, and DBP change in early age independent of atherosclerosis.
影响因子：
2.8
作者：
Brucks, S;Little, WC;Shihabi, ZK
通讯作者：
Shihabi, ZK
DOI：
10.1016/0735-1097(95)00282-8
发表时间：
1995-10-01
影响因子：
24
作者：
OLIVETTI, G;GIORDANO, G;ANVERSA, P
通讯作者：
ANVERSA, P
休息和运动时左心室充盈与年龄相关的下降。
DOI：
10.1152/ajpheart.1992.263.6.h1932
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Schulman,SP;Lakatta,EG;Fleg,JL;Lakatta,L;Becker,LC;Gerstenblith,G
通讯作者：
Gerstenblith,G