Structural covariance network centrality in maltreated youth with posttraumatic stress disorder.
Structural covariance network centrality in maltreated youth with posttraumatic stress disorder.
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DOI：
10.1016/j.jpsychires.2017.12.015
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Morey RA
中科院分区：
文献类型：
--
作者：
Sun D;Peverill MR;Swanson CS;McLaughlin KA;Morey RA
儿童期虐待与创伤后应激障碍（PTSD）以及青少年和成人精神病理学（包括重度抑郁症、双相情感障碍、物质使用障碍和其他医学合并症）的发病率升高有关。在患有（与没有）创伤后应激障碍的受虐待青少年中发现了灰质体积的变化。然而，很少有人知道的大脑结构协方差网络拓扑结构的变化来自皮质厚度在虐待青年创伤后应激障碍。高分辨率T1加权磁共振成像扫描来自人口统计学上匹配的患有PTSD的虐待青年（N = 24），没有PTSD的青年（N =64）和未虐待的健康对照组（n = 67）。来自148个皮质区域的皮质厚度数据被输入到参与者的区域间部分相关分析中。超阈值相关性构成了结构性脑网络中的连接，这些连接来自四种类型的中心性度量（度、介数、接近度和特征向量），估计了网络拓扑结构和节点的重要性。通过排列检验确定组间差异。与其他两组相比，受虐待的PTSD青年在左前扣带皮层表现出更大的中心性，这表明受虐待的PTSD青年特有的皮层网络拓扑结构。此外，与没有PTSD的青少年相比，受虐待的青少年在右眶额皮质中表现出较小的中心性，这表明这可能是虐待后PTSD的一个脆弱性因素。纵向随访目前的结果将有助于特征的作用，改变中心性发挥的脆弱性和弹性创伤后应激障碍儿童虐待。
Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter volume changes have been found in maltreated youth with (versus without) PTSD. However, little is known about the alterations of brain structural covariance network topology derived from cortical thickness in maltreated youth with PTSD. High-resolution T1-weighted magnetic resonance imaging scans were from demographically matched maltreated youth with PTSD (N = 24), without PTSD (N =64), and non-maltreated healthy controls (n = 67). Cortical thickness data from 148 cortical regions was entered into interregional partial correlation analyses across participants. The supra-threshold correlations constituted connections in a structural brain network derived from four types of centrality measures (degree, betweenness, closeness, and eigenvector) estimated network topology and the importance of nodes. Between-group differences were determined by permutation testing. Maltreated youth with PTSD exhibited larger centrality in left anterior cingulate cortex than the other two groups, suggesting cortical network topology specific to maltreated youth with PTSD. Moreover, maltreated youth with versus without PTSD showed smaller centrality in right orbitofrontal cortex, suggesting that this may represent a vulnerability factor to PTSD following maltreatment. Longitudinal follow-up of the present results will help characterize the role that altered centrality plays in vulnerability and resilience to PTSD following childhood maltreatment.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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