Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors.
Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors.
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DOI：
10.1016/j.bbr.2010.12.040
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发表时间：
2011-06-20
影响因子：
2.7
通讯作者：
Richtand, Neil M.
中科院分区：
文献类型：
--
作者：
Bronson, Stefanie L.;Ahlbrand, Rebecca;Horn, Paul S.;Kern, Joseph R.;Richtand, Neil M.
母亲在怀孕期间感染会增加后代患精神分裂症和相关疾病的风险。越来越多的证据表明，母体炎症反应介导了母体感染、大脑发育改变和行为结果之间的相互作用。母体对免疫激发反应的个体差异在多大程度上影响这些异常的发生尚不清楚。本研究探讨了母体对病毒模拟物聚肌苷酸：聚胞苷酸（poly I：C）反应的个体差异对后代行为的影响。我们观察到显着的变异性，妊娠大鼠的体重变化引起的聚I：C在妊娠第14天。此外，母体体重减轻的存在或不存在预测MK-801和安非他明刺激的运动异常的后代。MK-801刺激的运动在所有poly I：C处理母鼠的后代中发生改变;然而，存在或不存在母体体重减轻分别导致运动减少和适度增加。体重减轻的poly I：C处理的母鼠的成年后代表现出显著降低的安非他明刺激的运动，而体重未减轻的poly I：C处理的母鼠的后代表现与溶媒对照相似。社会隔离和母亲年龄的增加预测体重减轻聚I：C，但不是车辆注射。总之，这些数据确定了与母体对免疫激发的反应和暴露于母体免疫激活的后代的功能结果相关的环境因素。
Maternal infection during pregnancy elevates risk for schizophrenia and related disorders in offspring. Converging evidence suggests the maternal inflammatory response mediates the interaction between maternal infection, altered brain development, and behavioral outcome. The extent to which individual differences in the maternal response to immune challenge influence the development of these abnormalities is unknown. The present study investigated the impact of individual differences in maternal response to the viral mimic polyinosinic:polycytidylic acid (poly I:C) on offspring behavior. We observed significant variability in body weight alterations of pregnant rats induced by administration of poly I:C on gestational day 14. Furthermore, the presence or absence of maternal weight loss predicted MK-801 and amphetamine stimulated locomotor abnormalities in offspring. MK-801 stimulated locomotion was altered in offspring of all poly I:C treated dams; however, the presence or absence of maternal weight loss resulted in decreased and modestly increased locomotion, respectively. Adult offspring of poly I:C treated dams that lost weight exhibited significantly decreased amphetamine stimulated locomotion, while offspring of poly I:C treated dams without weight loss performed similarly to vehicle controls. Social isolation and increased maternal age predicted weight loss in response to poly I:C but not vehicle injection. In combination, these data identify environmental factors associated with the maternal response to immune challenge and functional outcome of offspring exposed to maternal immune activation.
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影响因子：
4.5
作者：
Ellman, Lauren M.;Deicken, Raymond F.;Vinogradov, Sophia;Kremen, William S.;Poole, John H.;Kern, David M.;Tsai, Wei Yann;Schaefer, Catherine A.;Brown, Alan S.
通讯作者：
Brown, Alan S.
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FUXE, K
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作者：
Breen, JG;Claggett, TW;Kimmel, CA
通讯作者：
Kimmel, CA
影响因子：
15.1
作者：
Cunningham, Colin;Campion, Suzanne;Perry, V. H.
通讯作者：
Perry, V. H.