Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8.
Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8.
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DOI：
10.1016/j.schres.2010.05.014
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发表时间：
2010-08
影响因子：
4.5
通讯作者：
Brown, Alan S.
中科院分区：
文献类型：
--
作者：
Ellman, Lauren M.;Deicken, Raymond F.;Vinogradov, Sophia;Kremen, William S.;Poole, John H.;Kern, David M.;Tsai, Wei Yann;Schaefer, Catherine A.;Brown, Alan S.
孕期母亲感染已多次与精神分裂症风险增加相关。然而，大多数病毒不会穿过胎盘；因此，对胎儿的损害似乎与母体对感染的抗病毒反应（例如促炎细胞因子）有关。胎儿接触促炎细胞因子白细胞介素 8 (IL-8) 与后代患精神分裂症的风险显着相关。本研究旨在确定精神分裂症病例和对照中胎儿暴露于 IL-8 与大脑结构变化之间的关联。受试者是精神分裂症发育侮辱和脑异常 (DIBS) 研究中诊断为精神分裂症的 17 例患者。通过半结构化访谈和病历审查来确定后代的精神病诊断。 IL-8 通过存档的产前血清测定确定，神经解剖区域的体积分析通过成年期 T1 加权磁共振成像获得。出于探索目的，纳入了八个对照。在病例中，胎儿暴露于IL-8增加与脑室脑脊液显着增加、左内嗅皮层体积显着减少和右后扣带回体积显着减少相关。右侧尾状核、壳核（双侧）和右侧颞上回的体积也出现了接近显着的下降。对照组之间没有观察到显着的关联。胎儿暴露于母体 IL-8 升高的情况下，会导致精神分裂症研究中一直涉及的大脑区域发生结构性神经解剖学改变。在子宫内暴露于 IL-8 升高可能部分解释了精神分裂症中常见的脑部紊乱。
Maternal infection during pregnancy has been repeatedly associated with increased risk for schizophrenia. Nevertheless, most viruses do not cross the placenta; therefore, the damaging effects to the fetus appear to be related to maternal antiviral responses to infection (e.g. proinflammatory cytokines). Fetal exposure to the proinflammatory cytokine interleukin-8 (IL-8) has been significantly associated with risk of schizophrenia in offspring. This study sought to determine the association between fetal exposure to IL-8 and structural brain changes among schizophrenia cases and controls. Subjects were 17 cases diagnosed with schizophrenia from the Developmental Insult and Brain Anomaly in Schizophrenia (DIBS) study. Psychiatric diagnoses were determined among offspring with semi-structured interviews and medical records review. IL-8 was determined from assays in archived prenatal sera and volumetric analyses of neuroanatomical regions were obtained from T1-weighted magnetic resonance imaging in adulthood. Eight controls were included for exploratory purposes. Among cases, fetal exposure to increases in IL-8 was associated with significant increases in ventricular cerebrospinal fluid, significant decreases in left entorhinal cortex volumes and significant decreases in right posterior cingulate volumes. Decreases that approached significance also were found in volumes of the right caudate, the putamen (bilaterally), and the right superior temporal gyrus. No significant associations were observed among controls. Fetal exposure to elevations in maternal IL-8 led to structural neuroanatomic alterations among cases in regions of the brain consistently implicated in schizophrenia research. In utero exposure to elevations in IL-8 may partially account for brain disturbances commonly found in schizophrenia.
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影响因子：
10.6
作者：
Ellman, Lauren M.;Yolken, Robert H.;Cannon, Tyrone D.
通讯作者：
Cannon, Tyrone D.
影响因子：
4.5
作者：
Deicken, RF;Pegues, M;Amend, D
通讯作者：
Amend, D
影响因子：
6.6
作者：
Susser, ES;Schaefer, CA;Wyatt, RJ
通讯作者：
Wyatt, RJ
影响因子：
1.8
作者：
Laskowska, Marzena;Laskowska, Katarzyna;Oleszczuk, Jan
通讯作者：
Oleszczuk, Jan
影响因子：
--
作者：
Insel, Beverly J.;Schaefer, Catherine A.;McKeague, Ian W.;Susser, Ezra S.;Brown, Alan S.
通讯作者：
Brown, Alan S.