Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive-compulsive disorder.
Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive-compulsive disorder.
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DOI：
10.1002/hbm.25699
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发表时间：
2022-02-15
影响因子：
4.8
通讯作者：
Nakao T
中科院分区：
文献类型：
--
作者：
Tomiyama H;Murayama K;Nemoto K;Tomita M;Hasuzawa S;Mizobe T;Kato K;Ohno A;Tsuruta S;Togao O;Hiwatashi A;Nakao T
最近的证据表明，前辅助运动区（pre - SMA）和额下回（IFG）在反应抑制中起重要作用。然而，没有研究调查静息状态下这些脑网络与强迫症（OCD）反应抑制之间的关系。我们进行了静息状态功能磁共振成像扫描，然后通过扫描仪外的停止信号任务测量了41名无药物OCD患者和49名健康对照（HC）参与者的反应抑制。我们探讨了强迫症和HC组在与运动反应抑制能力相关的SMA前和IFG功能连通性方面的差异。强迫症患者表现出较长的停止信号反应时间（SSRT）。与HC相比，强迫症患者的运动反应抑制能力与前SMA和IFG、下顶叶、前扣带背皮层、岛叶和前额叶前部皮层之间的功能连接表现出不同的相关性。对种子roi与全脑体素之间功能连通性差异的进一步分析显示，与HC相比，强迫症在SMA前和IFG之间表现出更大的功能连通性。此外，这种功能连通性与SSRT评分呈正相关。这些结果进一步揭示了皮层-纹状体-丘脑-皮层回路和扣带-眼突出网络区域的静息状态功能连通性特征，这是强迫症运动反应抑制受损的基础。特别地，我们强调了前SMA和IFG之间功能连接的改变对强迫症运动反应抑制的病理生理学的重要性。强迫症患者的运动反应抑制能力与静息状态下从SMA前到IPL、IFG、dACC和前岛的功能连通性之间存在显著差异。此外，与健康对照组相比，强迫症患者在SMA前和IFG之间表现出更大的功能连通性，这种功能连通性与运动反应抑制能力相关。
Recent evidence suggests that presupplementary motor area (pre‐SMA) and inferior frontal gyrus (IFG) play an important role in response inhibition. However, no study has investigated the relationship between these brain networks at resting‐state and response inhibition in obsessive–compulsive disorder (OCD). We performed resting‐state functional magnetic resonance imaging scans and then measured the response inhibition of 41 medication‐free OCD patients and 49 healthy control (HC) participants by using the stop‐signal task outside the scanner. We explored the differences between OCD and HC groups in the functional connectivity of pre‐SMA and IFG associated with the ability of motor response inhibition. OCD patients showed a longer stop‐signal reaction time (SSRT). Compared to HC, OCD patients exhibit different associations between the ability of motor response inhibition and the functional connectivity between pre‐SMA and IFG, inferior parietal lobule, dorsal anterior cingulate cortex, insula, and anterior prefrontal cortex. Additional analysis to investigate the functional connectivity difference from the seed ROIs to the whole brain voxels revealed that, compared to HC, OCD exhibited greater functional connectivity between pre‐SMA and IFG. Also, this functional connectivity was positively correlated with the SSRT score. These results provide additional insight into the characteristics of the resting‐state functional connectivity of the regions belonging to the cortico‐striato‐thalamo‐cortical circuit and the cingulo‐opercular salience network, underlying the impaired motor response inhibition of OCD. In particular, we emphasize the importance of altered functional connectivity between pre‐SMA and IFG for the pathophysiology of motor response inhibition in OCD. Obsessive–compulsive disorder patients had significantly different associations between the abilities of motor response inhibition and the resting‐state functional connectivity from pre‐SMA to IPL, IFG, dACC and anterior‐insula. Additionally, compared to healthy control, OCD exhibited greater functional connectivity between pre‐SMA and IFG, and this functional connectivity was correlated with the the abilities of motor response inhibition.
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影响因子：
3.2
作者：
Chambers, CD;Bellgrove, MA;Mattingley, JB
通讯作者：
Mattingley, JB
影响因子：
10.6
作者：
Aron, Adam R.
通讯作者：
Aron, Adam R.
影响因子：
7.4
作者：
D'Urso, Giordano;Brunoni, Andre R.;Mantovani, Antonio
通讯作者：
Mantovani, Antonio
影响因子：
5.3
作者：
Aron, Adam R.;Behrens, Tim E.;Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.
影响因子：
10.6
作者：
Bullmore, ET;Suckling, J;Brammer, MJ
通讯作者：
Brammer, MJ