Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis.
Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis.
复制标题
South-London（OASIS）2001 - 2020年的外展和支持：针对患有精神病风险的年轻人进行二十年的早期发现，预后和预防性护理。
DOI：
10.1016/j.euroneuro.2020.08.002
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
McGuire P
中科院分区：
文献类型：
--
作者：
Fusar-Poli P;Spencer T;De Micheli A;Curzi V;Nandha S;McGuire P
本研究旨在描述20年来南伦敦（OASIS）精神卫生服务对临床高危精神病（chrp）个体的早期发现、预后和预防护理。该研究对OASIS团队2001 - 2020年的活动进行了全面分析，包括核心领域：(i)服务特征，（ii）检测，（iii）预后，（iv）治疗和(v)临床研究。分析采用描述性统计、人群水平数据、精神病流行病学发病率、Kaplan Meier失效函数、Greenwood 95% ci和电子健康记录。OASIS是南伦敦和莫兹利（SLaM） NHS信托的一部分，该信托是欧洲最大的心理健康提供者，为城市总人口1,358,646人（16-35岁人口：454,525）提供服务。绿洲流域精神病发病率为58.3 - 71.9例/ 10万人年，高于全国平均水平41.5例/ 10万人年。OASIS是一个独立的，由nhs资助的，多学科的（团队领导，顾问和初级精神病学家，临床心理学家，精神卫生专业人员），过渡性（针对14-35岁的人）社区精神卫生服务，每年接待140名chrp患者。OASIS定期为多个本地社区组织提供全面的服务推广服务。许多机构向OASIS（2366）转介；大约三分之一的转诊患者最终达到了chrp标准。总体而言，600名chrp患者（55.33%为男性，平均年龄22.63岁，白人46.44%）接受了OASIS服务的治疗：80.43%符合精神病症状减轻，18.06%符合短暂和有限的间歇性精神病症状，1.51%符合遗传风险和恶化的chrp标准。所有chrp患者均接受认知行为治疗和心理社会支持；药物的使用取决于个人的需要。10年精神病的累积风险为0.365 （95%CI 0.302-0.437）。在6年的随访中，在三分之二未转变为精神病的个体中，79.24%仍然表现出一些心理健康问题，只有20.75%达到了完全的临床缓解。OASIS进行的研究包括临床、预后、神经生物学和介入研究，并利用了地方、国家和国际基础设施；在过去的十年中，与oasis相关的研究吸引了大约5000万英镑的资助收入，在国际数据库中被引用了5922次。未来的发展可能包括扩大OASIS以预防精神病以外的其他严重精神障碍，并促进转化风险预测和介入性研究。经过20年的活动，OASIS的尖端预防护理质量与转化研究创新相结合，巩固了该服务作为全球循证预防精神病的领先参考模式。
This study aims to describe twenty years of early detection, prognosis and preventive care in the Outreach and Support In South-London (OASIS) mental health service for individuals at Clinical High risk of psychosis (CHR-P). The study presents a comprehensive analysis of the 2001– 2020 activity of the OASIS team encompassing core domains: (i) service characteristics, (ii) detection, (iii) prognosis, (iv) treatment and (v) clinical research. The analyses employed descriptive statistics, population-level data, the epidemiological incidence of psychosis, Kaplan Meier failure functions and Greenwood 95% CIs and Electronic Health Records. OASIS is part of the South London and Maudsley (SLaM) NHS trust, the largest European mental health provider, serving a total urban population of 1,358,646 individuals (population aged 16-35: 454,525). Incidence of psychosis in OASIS's catchment area ranges from 58.3 to 71.9 cases per 100,000 person-years, and it is higher than the national average of 41.5 cases per 100,000 person-year. OASIS is a standalone, NHS-funded, multidisciplinary (team leader, consultant and junior psychiatrists, clinical psychologists, mental health professionals), transitional (for those aged 14-35 years) community mental health service with a yearly caseload of 140 CHR-P individuals. OASIS regularly delivers a comprehensive service promotion outreach to several local community organisations. Referrals to OASIS (2366) are made by numerous agencies; about one-third of the referrals eventually met CHR-P criteria. Overall, 600 CHR-P individuals (55.33% males, mean age 22.63 years, white ethnicity 46.44%) have been under the care of the OASIS service: 80.43% met attenuated psychotic symptoms, 18.06% brief and limited intermittent psychotic symptoms and 1.51% genetic risk and deterioration CHR-P criteria. All CHR-P individuals were offered cognitive behavioural therapy and psychosocial support; medications were used depending on individual needs. The cumulative risk of psychosis at ten years was 0.365 (95%CI 0.302-0.437). At six years follow-up, across two-third of individuals non-transitioning to psychosis, 79.24% still displayed some mental health problem, and only 20.75% achieved a complete clinical remission. Research conducted at OASIS encompassed clinical, prognostic, neurobiological and interventional studies and leveraged local, national and international infrastructures; over the past ten years, OASIS-related research attracted about £ 50 million of grant income, with 5,922 citations in the international databases. Future developments may include broadening OASIS to prevent other serious mental disorders beyond psychosis and fostering translational risk prediction and interventional research. With a twenty-years activity, OASIS’ cutting-edge quality of preventive care, combined with translational research innovations, consolidated the service as a leading reference model for evidence-based prevention of psychosis worldwide.
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影响因子：
8.1
作者：
Fusar-Poli, Paolo;De Micheli, Andrea;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
4.7
作者：
Fusar-Poli, Paolo;Estrade, Andres;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
11.3
作者：
Falkenberg, Irina;Valmaggia, Lucia;Fusar-Poli, Paolo
通讯作者：
Fusar-Poli, Paolo
影响因子：
6.9
作者：
Fusar-Poli, P.;Frascarelli, M.;McGuire, P.
通讯作者：
McGuire, P.
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison