Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet.
Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet.
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补充獐牙菜苦苷可预防高脂肪饮食小鼠与肥胖相关的慢性炎症和胰岛素抵抗
DOI：
10.1080/21623945.2021.1906510
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发表时间：
2021-12
期刊：
影响因子：
3.3
通讯作者：
Ding C
中科院分区：
文献类型：
--
作者：
Xu L;Li D;Zhu Y;Cai S;Liang X;Tang Y;Jin S;Ding C
肥胖的特点是低级别慢性炎症，这是胰岛素抵抗和非酒精性脂肪性肝病（NAFLD）的基础。獐牙菜黄素是一种环烯醚萜苷，据报道在动物模型中可以改善糖尿病和NAFLD。然而，獐牙菜黄素对肥胖相关炎症和胰岛素抵抗的影响尚未完全阐明。因此，本研究探讨了獐牙菜黄素对高脂饮食（HFD）诱导的肥胖小鼠炎症和胰岛素抵抗的影响。C57BL/6小鼠分别饲喂HFD或含獐牙菜黄素的HFD 8周。在小鼠的附睾白色脂肪组织（eWAT）和肝脏中评估肥胖引起的胰岛素抵抗和炎症。在小鼠中，獐牙獐牙苋苷减轻了hfd诱导的体重增加、葡萄糖耐受不良、氧化应激和胰岛素抵抗，并增强了胰岛素信号传导。与饲喂hfd的小鼠相比，獐牙菜黄素处理的小鼠eWAT的脂肪分解增加，脂肪细胞肥大和巨噬细胞浸润减少。此外，獐牙獐牙苦苷通过抑制肥胖小鼠eWAT和肝脏内p38 MAPK和NF-κB通路的激活，减轻了hfd介导的肝脏脂肪变性和炎症。综上所述，在肥胖小鼠中，添加獐牙菜苦苷可以减轻体重增加和肝脏脂肪变性，并减轻肥胖相关的炎症和胰岛素抵抗。
ABSTRACT Obesity is characterized by low-grade chronic inflammation, which underlies insulin resistance and non-alcoholic fatty liver disease (NAFLD). Swertiamarin is a secoiridoid glycoside that has been reported to ameliorate diabetes and NAFLD in animal models. However, the effects of swertiamarin on obesity-related inflammation and insulin resistance have not been fully elucidated. Thus, this study investigated the effects of swertiamarin on inflammation and insulin resistance in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed a HFD or HFD containing swertiamarin for 8 weeks. Obesity-induced insulin resistance and inflammation were assessed in the epididymal white adipose tissue (eWAT) and livers of the mice. Swertiamarin attenuated HFD-induced weight gain, glucose intolerance, oxidative stress, and insulin resistance, and enhanced insulin signalling in mice. Compared to HFD-fed mice, the swertiamarin-treated mice exhibited increased lipolysis and reduced adipocyte hypertrophy and macrophage infiltration in eWAT. Moreover, swertiamarin alleviated HFD-mediated hepatic steatosis and inflammation by suppressing activation of the p38 MAPK and NF-κB pathways within the eWAT and liver of obese mice. In conclusion, supplementation with swertiamarin attenuated weight gain and hepatic steatosis, and alleviated obesity-associated inflammation and insulin resistance, in obese mice.
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影响因子：
3.8
作者：
Huh JY;Park YJ;Ham M;Kim JB
通讯作者：
Kim JB
影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
7.7
作者：
Kitade H;Sawamoto K;Nagashimada M;Inoue H;Yamamoto Y;Sai Y;Takamura T;Yamamoto H;Miyamoto K;Ginsberg HN;Mukaida N;Kaneko S;Ota T
通讯作者：
Ota T
影响因子：
7.3
作者：
Kraakman MJ;Murphy AJ;Jandeleit-Dahm K;Kammoun HL
通讯作者：
Kammoun HL
DOI：
10.2147/dmsott.s7384
发表时间：
2010-08-30
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Hammond RA;Levine R
通讯作者：
Levine R