Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
复制标题
DOI：
10.1016/j.celrep.2020.108331
复制
发表时间：
2020-11-03
期刊：
影响因子：
8.8
通讯作者：
Kau AL
中科院分区：
文献类型：
--
作者：
Jaeger N;McDonough RT;Rosen AL;Hernandez-Leyva A;Wilson NG;Lint MA;Russler-Germain EV;Chai JN;Bacharier LB;Hsieh CS;Kau AL
稳态粘膜免疫反应通过与天然微生物自然进化的相互作用进行微调，将这些关系整合到实验模型中可以为人类疾病提供新的见解。在这里，我们利用一种适应小鼠的气道微生物——拟辛氏博德特氏菌 (Bph)，来研究慢性定植如何影响粘膜免疫和过敏性气道炎症 (AAI) 的发展。 Bph 定植会诱导分泌白细胞介素 17A (IL-17A) 的 T 辅助细胞分化，从而有助于控制细菌丰度。 Bph 定植可防止 AAI，并与分泌性白细胞蛋白酶抑制剂 (SLPI) 的产生增加相关，SLPI 是一种具有抗炎特性的抗菌肽。这些发现还得到了临床数据的支持，临床数据表明，较高水平的上呼吸道 SLPI 与更好的哮喘控制和嗜血杆菌（一种与 AAI 相关的细菌属）的存在相关。我们建议 SLPI 可以用作气道中有益的宿主共生关系的生物标志物。众所周知，哮喘是由气道微生物引起的。耶格等人。使用一种适应小鼠的细菌来证明气道定植会引起 Th17 反应，该反应与增加 SLPI（一种抗菌肽）和防止肺部炎症相关。在人类中，SLPI 与气道微生物群组成相关。
Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical data showing that higher levels of upper respiratory SLPI correlate both with greater asthma control and the presence of Haemophilus, a bacterial genus associated with AAI. We propose that SLPI could be used as a biomarker of beneficial host-commensal relationships in the airway. Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.
登录
查看更多内容
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
DOI：
10.1164/rccm.201304-0775oc
发表时间：
2013-11-15
影响因子：
24.7
作者：
Goleva, Elena;Jackson, Leisa P.;Leung, Donald Y. M.
通讯作者：
Leung, Donald Y. M.
影响因子：
1.7
作者：
Bankevich, Anton;Nurk, Sergey;Pevzner, Pavel A.
通讯作者：
Pevzner, Pavel A.