Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
复制标题
DOI：
10.1016/j.chembiol.2011.12.014
复制
发表时间：
2012-01-27
影响因子：
--
通讯作者：
Moore BS
中科院分区：
文献类型：
--
作者：
Gerwick WH;Moore BS
海洋生物是结构多样化和具有生物活性的次生代谢物的重要来源，其中几种次生代谢物激发了新型治疗剂的开发。这些成功的案例必须克服天然产品衍生药物所固有的困难，如药物的充分来源和与结构复杂性有关的问题。尽管如此，几种海洋衍生药物现已获得批准，其中大多数是“一类”药物，过去几年出现了7种药物中的5种。此外，还有丰富的临床和临床前海洋化合物流水线，表明它们继续应用于人类医学。近年来，人们对这些药物是如何生物合成组装的了解有所加快，特别是通过跨学科的方法，其中一些基因簇的创新操作和重新设计正在产生与天然产品相比具有更强药用性能的新型药物。
Marine life forms are an important source of structurally-diverse and biologically-active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. These success stories have had to overcome difficulties inherent to natural products-derived drugs, such as adequate sourcing of the agent and issues related to structural complexity. Nevertheless, several marine-derived agents are now approved, most as `first-in-class' drugs, with 5 of 7 appearing in the past few years. Additionally, there is a rich pipeline of clinical and pre-clinical marine compounds to suggest their continued application in human medicine. Understanding of how these agents are biosynthetically assembled has accelerated in recent years, especially through interdisciplinary approaches, and innovative manipulations and re-engineering of some of these gene clusters are yielding novel agents of enhanced pharmaceutical properties compared with the natural product.
登录
查看更多内容
影响因子：
16.6
作者：
Gulder, Tobias A. M.;Moore, Bradley S.
通讯作者：
Moore, Bradley S.
影响因子：
14.8
作者：
Fisch, Katja M.;Gurgui, Cristian;Piel, Joern
通讯作者：
Piel, Joern
DOI：
10.1021/ci0200467
发表时间：
2003-01-01
期刊：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子：
--
作者：
Feher, M;Schmidt, JM
通讯作者：
Schmidt, JM
影响因子：
14.8
作者：
Donia, Mohamed S.;Ravel, Jacques;Schmidt, Eric W.
通讯作者：
Schmidt, Eric W.
影响因子：
2.8
作者：
Gonzalez, David J.;Haste, Nina M.;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.