Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia.
Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia.
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DOI：
10.1007/s00415-022-11490-4
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发表时间：
2023-03
影响因子：
6
通讯作者：
Peall, Kathryn J.
中科院分区：
文献类型：
--
作者：
Bailey, Grace A.;Matthews, Clare;Szewczyk-krolikowski, Konrad;Moore, Peter;Komarzynski, Sandra;Davies, Elin Haf;Peall, Kathryn J.
高达70%的成人型特发性局灶性颈肌张力障碍（AOIFCD）患者报告睡眠困难。为了评估睡眠结构，使用腕戴式加速度计设备的大型队列研究已经成为小型多导睡眠图研究的替代方案。为了测量睡眠/清醒周期期间的活动，受试者在非优势手腕上连续佩戴消费级腕部设备（Garmin vivosmart 4）超过7天，同时通过专用应用程序完成每日睡眠日记和标准化睡眠和非运动问卷。睡眠测量值来自使用先前发布的验证算法捕获的原始三轴加速度和心率值。数据收集自50名被诊断患有AOIFCD的个体和47名年龄和性别匹配的对照。AOIFCD患者自我报告的日间过度嗜睡（p = 0.04）和睡眠质量受损（p = 0.03）水平显著较高，而加速度计测量发现，与对照组相比，AOIFCD队列的总睡眠时间（p = 0.004）和NREM睡眠时间（p = 0.009）显著更长。总的来说，可穿戴设备获得的睡眠参数与自我报告的睡眠日记和视觉模拟量表记录之间的一致性有限。这项研究表明，使用消费级可穿戴设备来大规模估计肌张力障碍队列的睡眠指标具有潜在的可行性。与对照组相比，被诊断患有AOIFCD的人的睡眠结构发生了改变，特别是总睡眠时间和NREM睡眠时间更长。这些发现表明，先前报道的脑干回路和5-羟色胺神经传递的中断可能有助于运动和睡眠病理生理学。在线版本包含补充材料，可通过10.1007/s 00415 -022-11490-4获得。
Up to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture. To measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app. Sleep measures were derived from the captured raw triaxial acceleration and heart rate values using previously published validated algorithms. Data were collected from 50 individuals diagnosed with AOIFCD and 47 age- and sex-matched controls. Those with AOIFCD self-reported significantly higher levels of excessive daytime sleepiness (p = 0.04) and impaired sleep quality (p = 0.03), while accelerometer measurements found the AOIFCD cohort to have significantly longer total sleep times (p = 0.004) and time spent in NREM sleep (p = 0.009), compared to controls. Overall, there was limited agreement between wearable-derived sleep parameters, and self-reported sleep diary and visual analogue scale records. This study shows the potential feasibility of using consumer-grade wearable devices in estimating sleep measures at scale in dystonia cohorts. Those diagnosed with AOIFCD were observed to have altered sleep architecture, notably longer total sleep time and NREM sleep, compared to controls. These findings suggest that previously reported disruptions to brainstem circuitry and serotonin neurotransmission may contribute to both motor and sleep pathophysiology. The online version contains supplementary material available at 10.1007/s00415-022-11490-4.
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影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
影响因子：
4.1
作者：
Eichenseer, Sheila R.;Stebbins, Glenn T.;Comella, Cynthia L.
通讯作者：
Comella, Cynthia L.
影响因子：
6
作者：
Paus, Sebastian;Gross, Jennifer;Abele, Michael
通讯作者：
Abele, Michael
影响因子：
4.8
作者：
Landry GJ;Best JR;Liu-Ambrose T
通讯作者：
Liu-Ambrose T
影响因子：
5.6
作者：
Chen, Xiaoli;Wang, Rui;Redline, Susan
通讯作者：
Redline, Susan