Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone.
Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone.
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早期生命维生素D耗竭改变了生长和成熟骨骼骨骼负荷的产后反应。
DOI：
10.1371/journal.pone.0190675
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Bishop NJ
中科院分区：
文献类型：
--
作者：
Borg SA;Buckley H;Owen R;Marin AC;Lu Y;Eyles D;Lacroix D;Reilly GC;Skerry TM;Bishop NJ
越来越多的证据表明，生命早期接触维生素 D 对以后的骨骼健康有持续影响；生命早期维生素 D 水平较低与儿童时期骨骼尺寸较小以及成年后骨折风险增加有关，与后来的维生素 D 状况无关。所有年龄段骨量获取的一个主要决定因素是机械负荷。我们在动物模型系统中测试了这一假设，即生命早期维生素 D 消耗会导致对机械负荷的反应消失，从而导致儿童期和成年期的骨骼尺寸、质量和强度减少。创建了一个小鼠模型，其中怀孕的母鼠要么缺乏维生素 D，要么补充维生素 D，它们的后代在断奶时转向补充维生素 D 的饮食。对后代的胫骨进行机械负载，并在生长期间和骨骼成熟后测量骨骼结构、外在强度和生长。维生素 D 消耗小鼠的后代表现出未负重肢体的骨量较低，并且骨骼生长过程中和骨骼成熟后对负重的反应减少了骨量增长。生命早期维生素 D 消耗导致骨骼强度降低并改变骨骼生物力学特性。这些发现表明，生命早期的维生素 D 状况可能在一定程度上决定了骨质疏松和骨折的倾向，而骨质疏松和骨折会影响许多人的晚年生活。
There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later vitamin D status. A major determinant of bone mass acquisition across all ages is mechanical loading. We tested the hypothesis in an animal model system that early life vitamin D depletion results in abrogation of the response to mechanical loading, with consequent reduction in bone size, mass and strength during both childhood and adulthood. A murine model was created in which pregnant dams were either vitamin D deficient or replete, and their offspring moved to a vitamin D replete diet at weaning. Tibias of the offspring were mechanically loaded and bone structure, extrinsic strength and growth measured both during growth and after skeletal maturity. Offspring of vitamin D deplete mice demonstrated lower bone mass in the non loaded limb and reduced bone mass accrual in response to loading in both the growing skeleton and after skeletal maturity. Early life vitamin D depletion led to reduced bone strength and altered bone biomechanical properties. These findings suggest early life vitamin D status may, in part, determine the propensity to osteoporosis and fracture that blights later life in many individuals.
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影响因子：
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作者：
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作者：
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通讯作者：
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