Evidence for a relationship between bilateral coordination during complex gait tasks and freezing of gait in Parkinson's disease.
Evidence for a relationship between bilateral coordination during complex gait tasks and freezing of gait in Parkinson's disease.
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DOI：
10.1016/j.parkreldis.2012.05.019
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发表时间：
2012-11
影响因子：
4.1
通讯作者：
Earhart GM
中科院分区：
文献类型：
--
作者：
Peterson DS;Plotnik M;Hausdorff JM;Earhart GM
步态冻结是帕金森氏病(PD)患者常见的衰弱步态障碍。尽管冻结的基本机制尚不清楚，但作为阶段协调指数衡量的双边步骤协调已被认为与冻结有关。然而，在转身和后退行走等与冻结相关的任务中，还没有测量到相位协调指数。了解在与冻结相关的任务过程中双边协调如何变化，可能会提高我们对冻结原因的理解。12名帕金森病患者冷冻(冰柜)，19名帕金森病患者不冷冻(非冰柜)，以及10名健康的、年龄匹配的老年人参加。评估一般运动疾病的严重程度和冰冻的严重程度。计算受试者在前向行走、后向行走、小半径转弯、大半径转弯时的位相协调性指数。冷冻组和非冷冻组的病程和一般运动严重程度相似。与非冷冻室和对照组相比，冷冻室的步进式协调(以相位协调指数衡量)明显更差。转身和向后行走是与冻结有关的任务，导致向前行走的协调性较差。协调性与冰冻的严重程度有关，协调性越差与冰冻越严重相关。这些结果为帕金森病患者的步态协调与冰冻有关提供了证据。识别与冰冻相关的变量可能提供对这一症状潜在因素的洞察，并可能为康复干预提供信息，以减少其在帕金森病中的发生。
Freezing of gait is a debilitating and common gait disturbance observed in individuals with Parkinson’s disease (PD). Although the underlying mechanisms of freezing remain unclear, bilateral coordination of steps, measured as a phase coordination index, has been suggested to be related to freezing. Phase coordination index has not, however, been measured during tasks associated with freezing such as turning and backward walking. Understanding how bilateral coordination changes during tasks associated with freezing may improve our understanding of the causes of freezing. Twelve individuals with PD who freeze (freezers), 19 individuals with PD who do not freeze (non-freezers), and 10 healthy, age-matched older adults participated. General motor disease severity and freezing severity were assessed. Phase coordination index was calculated for all subjects during forward walking, backward walking, continuous turning in small radius circles, and turning in large radius circles. Freezers and non-freezers had similar disease duration and general motor severity. Stepping coordination (measured as phase coordination index) was significantly worse in freezers compared to non-freezers and controls. Turning and backward walking, tasks related to freezing, resulted in worse coordination with respect to forward walking. Coordination was associated with severity of freezing scores such that worse coordination was correlated with more severe freezing. These results provide evidence that stepping coordination is related to freezing in people with PD. Identifying variables associated with freezing may provide insights into factors underlying this symptom, and may inform rehabilitative interventions to reduce its occurrence in PD.
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