Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection.
Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection.
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DOI：
10.1016/j.jaci.2008.05.033
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发表时间：
2008-07
期刊：
影响因子：
--
通讯作者：
Siliciano RF
中科院分区：
文献类型：
--
作者：
Shen L;Siliciano RF
尽管高效抗逆转录病毒疗法（HAART）可以将HIV-1病毒血症降低至低于临床检测限的水平，但病毒仍存在于储存库中，并且在血浆中可以发现痕量水平的游离病毒体。这种残留病毒血症是否代表了HAART后仍在持续的复制循环，或者仅仅是病毒从稳定的宿主中释放，一直存在争议。在这里，我们总结了HAART可以停止正在进行的复制周期的证据。证据来自对残留病毒血症的详细分析，表明其具有存档和非演变性质。此外，新的药效学措施，包括以前被忽略的斜率参数提供了第一个真实的指标，以及HAART实际上如何抑制体内病毒复制。总之，这些结果表明，HAART控制病毒复制的最终理论潜力已经达到。根除感染的进展将需要新的方法来靶向稳定的储库，即使病毒复制完全停止也会持续存在。
Although highly active antiretroviral therapy (HAART) can reduce HIV-1 viremia to levels that are below the limit of detection of clinical assays, the virus persists in reservoirs and trace levels of free virions can be found in the plasma. Whether this residual viremia represents ongoing cycles of replication continuing despite HAART or simply the release of virus from stable reservoirs has been controversial. Here we summarize the evidence that HAART can stop ongoing cycles of replication. The evidence comes from a detailed analysis of the residual viremia, which shows it to be archival and non-evolving in character. In addition, new pharmacodynamic measures incorporating a previous ignored slope parameter have provided the first real indication of how well HAART actually suppresses viral replication in vivo. Together, these results argue that the ultimate theoretical potential of HAART to control viral replication has already been reached. Progress towards eradication of the infection will require novel approaches to target the stable reservoirs that persist even when viral replication is completely halted.
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影响因子：
4.9
作者：
Hertogs, K;de Béthune, MP;Pauwels, R
通讯作者：
Pauwels, R
DOI：
10.1073/pnas.94.24.13193
发表时间：
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