Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism.
Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism.
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DOI：
10.1186/s40779-018-0162-9
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发表时间：
2018-05-14
影响因子：
21.1
通讯作者：
Liu CT
中科院分区：
文献类型：
--
作者：
Huang B;Li DG;Huang Y;Liu CT
航天和地面微重力模拟实验表明，微重力会影响微生物的生长和新陈代谢。尽管微重力及其类似物对微生物的影响的研究已有 50 多年的历史，但在不同的实验中经常报告看似合理的相互矛盾和多样化的结果，特别是在微生物生长和次生代谢方面。到目前为止，仅研究了几种典型微生物对微重力的反应；由于技术和后勤障碍，对这些微生物对太空微重力的遗传和表型反应的系统研究仍然不足。这些研究中使用不同的测试菌株和次级代谢物似乎导致了不同且相互矛盾的结果。此外，微生物细胞周围细胞外微环境的微妙变化在微生物生长和次生代谢的多样化反应中发挥着关键作用。因此，“间接”效应代表了解释微生物中这些现象发生的合理途径。这篇综述总结了当前关于微生物生长和次生代谢因航天及其类似事件而发生变化的知识，并讨论了各种相互矛盾的结果。此外，还为未来研究太空微重力对微生物生长和次生代谢的影响提出了建议。本文的在线版本 (10.1186/s40779-018-0162-9) 包含补充材料，可供授权用户使用。
Spaceflight and ground-based microgravity analog experiments have suggested that microgravity can affect microbial growth and metabolism. Although the effects of microgravity and its analogs on microorganisms have been studied for more than 50 years, plausible conflicting and diverse results have frequently been reported in different experiments, especially regarding microbial growth and secondary metabolism. Until now, only the responses of a few typical microbes to microgravity have been investigated; systematic studies of the genetic and phenotypic responses of these microorganisms to microgravity in space are still insufficient due to technological and logistical hurdles. The use of different test strains and secondary metabolites in these studies appears to have caused diverse and conflicting results. Moreover, subtle changes in the extracellular microenvironments around microbial cells play a key role in the diverse responses of microbial growth and secondary metabolisms. Therefore, “indirect” effects represent a reasonable pathway to explain the occurrence of these phenomena in microorganisms. This review summarizes current knowledge on the changes in microbial growth and secondary metabolism in response to spaceflight and its analogs and discusses the diverse and conflicting results. In addition, recommendations are given for future studies on the effects of microgravity in space on microbial growth and secondary metabolism. The online version of this article (10.1186/s40779-018-0162-9) contains supplementary material, which is available to authorized users.
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作者：
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DOI：
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