N-acetyl-aspartyl-glutamate detection in the human brain at 7 Tesla by echo time optimization and improved Wiener filtering.
N-acetyl-aspartyl-glutamate detection in the human brain at 7 Tesla by echo time optimization and improved Wiener filtering.
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DOI：
10.1002/mrm.25007
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发表时间：
2014-10
影响因子：
3.3
通讯作者：
Shen, Jun
中科院分区：
文献类型：
--
作者：
An, Li;Li, Shizhe;Wood, Emily T.;Reich, Daniel S.;Shen, Jun
我们报道了通过te优化的点分辨光谱（PRESS）和改进的维纳滤波增强的信号检测，以测量人脑在7T时的n -乙酰-天冬氨酸-谷氨酸（NAAG）。利用内部开发的高效数值模拟程序，发现(TE1, TE2) = (26,72) ms的PRESS序列相对于重叠的Glu信号可以最大化NAAG信号。提出了一种新的维纳滤波水参考反褶积方法，以减少由于B0不均匀性和涡流引起的代谢物峰的加宽和畸变。蒙特卡罗仿真结果表明，与原有的维纳滤波方法相比，新的维纳滤波方法具有更高的光谱分辨率，减少了光谱伪影，并提高了NAAG量化的精度。体内光谱和信号失真点扩展函数证实了新的维纳滤波方法提高了光谱分辨率，减少了光谱伪影。te优化的PRESS与新的维纳滤波方法相结合，可以充分利用2.05 ppm的NAAG单线信号和2.18 ppm的NAAG多路信号来量化NAAG。为了更准确地表征维纳滤波的线形失真，需要B0场图和分割的解剖图像来排除脑脊液的影响。
We report enhanced signal detection for measuring N-acetyl-aspartyl-glutamate (NAAG) in the human brain at 7T by TE-optimized point-resolved spectroscopy (PRESS) and improved Wiener filtering. Using a highly efficient in-house developed numerical simulation program, a PRESS sequence with (TE1, TE2) = (26, 72) ms was found to maximize the NAAG signals relative to the overlapping Glu signals. A new Wiener filtering water reference deconvolution method was developed to reduce broadening and distortions of metabolite peaks caused by B0 inhomogeneity and eddy currents. Monte Carlo simulation results demonstrated that the new Wiener filtering method offered higher spectral resolution, reduced spectral artifacts, and higher accuracy in NAAG quantification compared to the original Wiener filtering method. In vivo spectra and point spread functions of signal distortion confirmed that the new Wiener filtering method lead to improved spectral resolution and reduced spectral artifacts. TE-optimized PRESS in combination with a new Wiener filtering method made it possible to fully utilize both the NAAG singlet signal at 2.05 ppm and the NAAG multiplet signal at 2.18 ppm in the quantification of NAAG. A more accurate characterization of lineshape distortion for Wiener filtering needs B0 field maps and segmented anatomical images to exclude contribution from cerebral spinal fluid.
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影响因子：
4.4
作者：
An, Li;van der Veen, Jan Willem;Li, Shizhe;Thomasson, David M.;Shen, Jun
通讯作者：
Shen, Jun
影响因子：
6.6
作者：
Rowland, Laura M.;Kontson, Kimberly;Barker, Peter B.
通讯作者：
Barker, Peter B.
影响因子：
2.2
作者：
Cavassila, S;Deval, S;Graveron-Demilly, D
通讯作者：
Graveron-Demilly, D
DOI：
10.1006/jmra.1994.1108
发表时间：
1994-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES A
影响因子：
--
作者：
STARCUK, Z;BARTUSEK, K;STARCUK, Z
通讯作者：
STARCUK, Z
影响因子：
3.3
作者：
Choi, Changho;Ghose, Subroto;Ganjil, Sandeep
通讯作者：
Ganjil, Sandeep