Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis.
Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis.
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DOI：
10.1177/1352458512436593
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Cross AH
中科院分区：
文献类型：
--
作者：
Klawiter EC;Xu J;Naismith RT;Benzinger TL;Shimony JS;Lancia S;Snyder AZ;Trinkaus K;Song SK;Cross AH
多发性硬化症（MS）和视神经肌萎缩症（NMO）均累及脊髓，但病理学上有显著差异。确定扩散张量成像（DTI）在区分T2病变内外的NMO和MS脊髓病变中的应用。横肌痉挛临床发作≥12个月的受试者接受了新型经轴颈脊髓DTI序列。包括10名NMO受试者、10名MS受试者和10名健康对照者。在T2影响的白色区域内，与健康对照相比，NMO和MS的径向扩散率均增加（分别为p<0.001），并且NMO的增加程度大于MS（p<0.001）。与对照组相比，NMO和MS的T2病变轴向扩散率均降低（p<0.001，p=0.001），但两种疾病之间无差异。在每种疾病中，T2病变上游和下游的白色区域内的径向扩散率和FA与对照组不同。与MS相比，在NMO中，通过扩散张量成像获得的脊髓白色物质束内的径向扩散率更高，这与在NMO中观察到的已知更大的组织破坏一致。DTI还检测到T2病变外的组织改变，可能是顺行性和逆行性变性的替代。
Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology. Determine the utility of diffusion tensor imaging (DTI) to differentiate the spinal cord lesions of NMO from MS within and outside T2 lesions. Subjects ≥12 months from a clinical episode of transverse myelitis underwent a novel transaxial cervical spinal cord DTI sequence. Ten subjects with NMO, 10 with MS, and 10 healthy controls were included. Within T2 affected white matter regions, radial diffusivity was increased in both NMO and MS compared to healthy controls (p<0.001, respectively), and to a greater extent in NMO than MS (p<0.001). Axial diffusivity was decreased in T2 lesions in both NMO and MS compared to controls (p<0.001, p=0.001), but did not differ between the two diseases. Radial diffusivity and FA within white matter regions upstream and downstream of T2 lesions were different from controls in each disease. Higher radial diffusivity, within spinal cord white matter tracts derived from diffusion tensor imaging were appreciated in NMO compared to MS, consistent with the known greater tissue destruction seen in NMO. DTI also detected tissue alterations outside T2 lesions, and may be a surrogate of anterograde and retrograde degeneration.
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影响因子：
5.7
作者：
Klawiter, Eric C.;Schmidt, Robert E.;Trinkaus, Kathryn;Liang, Hsiao-Fang;Budde, Matthew D.;Naismith, Robert T.;Song, Sheng-Kwei;Cross, Anne H.;Benzinger, Tammie L.
通讯作者：
Benzinger, Tammie L.
影响因子：
9.9
作者：
Naismith, R. T.;Xu, J.;Song, S. -K.
通讯作者：
Song, S. -K.
影响因子：
9.9
作者：
Benedetti, B.;Valsasina, P.;Filippi, M.
通讯作者：
Filippi, M.
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
影响因子：
5.7
作者：
Cohen-Adad, J.;El Mendili, M-M.;Benali, H.
通讯作者：
Benali, H.